Cerebrovascular alterations in Alzheimer disease incidental or pathogenic?

Costantino Iadecola, Rebecca F. Gottesman

Research output: Contribution to journalArticlepeer-review

Abstract

Alzheimer disease (AD)-the leading cause of cognitive impairment in the elderly-has traditionally been considered a disease of neurons. Structural and functional alterations of cerebral blood vessels also occur, but direct evidence of a causal involvement in the pathobiology of the disease has been lacking. This viewpoint will review new data that may help shed light into the intriguing association between vascular and neurodegenerative pathology.

Original languageEnglish (US)
Pages (from-to)406-408
Number of pages3
JournalCirculation research
Volume123
Issue number4
DOIs
StatePublished - 2018

Keywords

  • Alzheimer disease
  • Blood-brain barrier
  • Dementia
  • Neurons
  • Risk factors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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