Cerebrospinal fluid penetration and bacteriostatic activity of linezolid against Enterococcus faecalis in a child with a ventriculoperitoneal shunt infection

Aaron M. Milstone; James Dick; Benjamin Carson; George K. Siberry

doi:10.1159/000106392

Cerebrospinal fluid penetration and bacteriostatic activity of linezolid against Enterococcus faecalis in a child with a ventriculoperitoneal shunt infection

Aaron M. Milstone, James Dick, Benjamin Carson, George K. Siberry

School of Medicine

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

We report a 4-year-old girl with a complicated Enterococcus faecalis ventriculoperitoneal shunt infection who failed vancomycin therapy. We demonstrate linezolid's high CSF penetration and its CSF bacteriostatic activity against E. faecalis. Linezolid may be a good alternative for treatment of ventriculoperitoneal shunt infections in cases of vancomycin-resistant organisms or apparent treatment failures.

Original language	English (US)
Pages (from-to)	406-409
Number of pages	4
Journal	Pediatric Neurosurgery
Volume	43
Issue number	5
DOIs	https://doi.org/10.1159/000106392
State	Published - Sep 2007

Keywords

Bacteriostatic activity
Enterococcus faecalis
Linezolid
Ventriculoperitoneal shunt

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Surgery
Clinical Neurology

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10.1159/000106392

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abstract = "We report a 4-year-old girl with a complicated Enterococcus faecalis ventriculoperitoneal shunt infection who failed vancomycin therapy. We demonstrate linezolid's high CSF penetration and its CSF bacteriostatic activity against E. faecalis. Linezolid may be a good alternative for treatment of ventriculoperitoneal shunt infections in cases of vancomycin-resistant organisms or apparent treatment failures.",

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AU - Dick, James

AU - Carson, Benjamin

AU - Siberry, George K.

PY - 2007/9

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AB - We report a 4-year-old girl with a complicated Enterococcus faecalis ventriculoperitoneal shunt infection who failed vancomycin therapy. We demonstrate linezolid's high CSF penetration and its CSF bacteriostatic activity against E. faecalis. Linezolid may be a good alternative for treatment of ventriculoperitoneal shunt infections in cases of vancomycin-resistant organisms or apparent treatment failures.

KW - Bacteriostatic activity

KW - Enterococcus faecalis

KW - Linezolid

KW - Ventriculoperitoneal shunt

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Cerebrospinal fluid penetration and bacteriostatic activity of linezolid against Enterococcus faecalis in a child with a ventriculoperitoneal shunt infection

Abstract

Keywords

ASJC Scopus subject areas

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