Cerebrospinal fluid penetration and bacteriostatic activity of linezolid against Enterococcus faecalis in a child with a ventriculoperitoneal shunt infection

Aaron M. Milstone, James Dick, Benjamin Carson, George K. Siberry

Research output: Contribution to journalArticlepeer-review

Abstract

We report a 4-year-old girl with a complicated Enterococcus faecalis ventriculoperitoneal shunt infection who failed vancomycin therapy. We demonstrate linezolid's high CSF penetration and its CSF bacteriostatic activity against E. faecalis. Linezolid may be a good alternative for treatment of ventriculoperitoneal shunt infections in cases of vancomycin-resistant organisms or apparent treatment failures.

Original languageEnglish (US)
Pages (from-to)406-409
Number of pages4
JournalPediatric Neurosurgery
Volume43
Issue number5
DOIs
StatePublished - Sep 1 2007

Keywords

  • Bacteriostatic activity
  • Enterococcus faecalis
  • Linezolid
  • Ventriculoperitoneal shunt

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

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