Cerebrospinal fluid monoamine metabolites in patients with infantile spasms

Faye Silverstein, Michael V Johnston

Research output: Contribution to journalArticle

Abstract

We measured CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) by high-performance liquid chromatography in seven children with infantile spasms and in a group of ageand sex-matched controls. The mean concentration of the serotonin metabolite 5-HIAA was 40% (p <0.01) lower in the infantile spasms group as compared with controls; HVA levels were similar in both groups. The data provide additional evidence that serotonin metabolism is abnormal in patients with infantile spasms.

Original languageEnglish (US)
Pages (from-to)102-105
Number of pages4
JournalNeurology
Volume34
Issue number1
StatePublished - 1984
Externally publishedYes

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Infantile Spasms
Cerebrospinal Fluid
Homovanillic Acid
Hydroxyindoleacetic Acid
Serotonin
High Pressure Liquid Chromatography
Metabolism
High-performance Liquid Chromatography

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Cerebrospinal fluid monoamine metabolites in patients with infantile spasms. / Silverstein, Faye; Johnston, Michael V.

In: Neurology, Vol. 34, No. 1, 1984, p. 102-105.

Research output: Contribution to journalArticle

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