Cerebrospinal fluid monoamine metabolites in patients with infantile spasms

Faye Silverstein, Michael V. Johnston

Research output: Contribution to journalArticlepeer-review

Abstract

We measured CSF levels of homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) by high-performance liquid chromatography in seven children with infantile spasms and in a group of ageand sex-matched controls. The mean concentration of the serotonin metabolite 5-HIAA was 40% (p < 0.01) lower in the infantile spasms group as compared with controls; HVA levels were similar in both groups. The data provide additional evidence that serotonin metabolism is abnormal in patients with infantile spasms.

Original languageEnglish (US)
Pages (from-to)102-105
Number of pages4
JournalNeurology
Volume34
Issue number1
DOIs
StatePublished - Jan 1984
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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