Cerebrospinal fluid dynamics between the basal cisterns and the subarachnoid space of the optic nerve in patients with papilloedema

Hanspeter Esriel Killer, Gregor Peter Jaggi, Neil R Miller, Andreas R. Huber, Hans Landolt, Angel Mironov, Peter Meyer, Luca Remonda

Research output: Contribution to journalArticle

Abstract

Aims: To determine cerebrospinal fluid (CSF) dynamics between intracranial CSF spaces and CSF in the subarachnoid space (SAS) of optic nerves (ONs) in 10 patients with papilloedema. Methods: Prospective assessment of 10 patients with papilloedema and two control subjects using CT cisternography and analysis of CSF for the presence of lipocalin-like prostaglandin D synthase (betatrace protein). Results: CT cisternography showed a progressively reduced influx of contrast-loaded CSF from intracranial CSF spaces into the SAS. The lowest concentration of contrast-loaded CSF was found in the region of the ON immediately behind the globe, where the ON sheath was widened (possibly by unfolding) in all patients compared with normal subjects. The concentration of lipocalin-like prostaglandin D synthase differed between the spinal CSF and the CSF in the SAS, with a markedly higher concentration in the SAS. Conclusion: The results of this study suggest that CSF turnover in the SAS of the ON is reduced in patients with papilloedema from various causes and that the composition of CSF differs between spinal CSF and that surrounding the ON.

Original languageEnglish (US)
Pages (from-to)822-827
Number of pages6
JournalBritish Journal of Ophthalmology
Volume95
Issue number6
DOIs
StatePublished - Jun 2011

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Papilledema
Subarachnoid Space
Hydrodynamics
Optic Nerve
Cerebrospinal Fluid
prostaglandin R2 D-isomerase
Lipocalins

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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Cerebrospinal fluid dynamics between the basal cisterns and the subarachnoid space of the optic nerve in patients with papilloedema. / Killer, Hanspeter Esriel; Jaggi, Gregor Peter; Miller, Neil R; Huber, Andreas R.; Landolt, Hans; Mironov, Angel; Meyer, Peter; Remonda, Luca.

In: British Journal of Ophthalmology, Vol. 95, No. 6, 06.2011, p. 822-827.

Research output: Contribution to journalArticle

Killer, Hanspeter Esriel ; Jaggi, Gregor Peter ; Miller, Neil R ; Huber, Andreas R. ; Landolt, Hans ; Mironov, Angel ; Meyer, Peter ; Remonda, Luca. / Cerebrospinal fluid dynamics between the basal cisterns and the subarachnoid space of the optic nerve in patients with papilloedema. In: British Journal of Ophthalmology. 2011 ; Vol. 95, No. 6. pp. 822-827.
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