Cerebrospinal fluid corticotropin-releasing hormone in depression: Relationship to noradrenergic function

Alec Roy; David Pickar; Markku Linnoila; George P. Chrousos; Philip W. Gold

doi:10.1016/0165-1781(87)90083-7

Cerebrospinal fluid corticotropin-releasing hormone in depression: Relationship to noradrenergic function

Alec Roy, David Pickar, Markku Linnoila, George P. Chrousos, Philip W. Gold

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

We investigated the neurotransmitter regulation of corticotropin-releasing hormone (CRH). Among 21 depressed patients cerebrospinal fluid (CSF) levels of CRH significantly correlated with urinary outputs of norepinephrine and its major metabolites, and there were trends for significant correlations with both CSF and plasma levels of norepinephrine. These results suggest that CRH may be associated with the dysregulation of the norepinephrine system that is found in desperation.

Original language	English (US)
Pages (from-to)	229-237
Number of pages	9
Journal	Psychiatry Research
Volume	20
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(87)90083-7
State	Published - 1987
Externally published	Yes

Keywords

Corticotropin-releasing hormone
depression
norepinephrine

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry
General Psychology

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10.1016/0165-1781(87)90083-7

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AU - Chrousos, George P.

AU - Gold, Philip W.

PY - 1987

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AB - We investigated the neurotransmitter regulation of corticotropin-releasing hormone (CRH). Among 21 depressed patients cerebrospinal fluid (CSF) levels of CRH significantly correlated with urinary outputs of norepinephrine and its major metabolites, and there were trends for significant correlations with both CSF and plasma levels of norepinephrine. These results suggest that CRH may be associated with the dysregulation of the norepinephrine system that is found in desperation.

KW - Corticotropin-releasing hormone

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KW - norepinephrine

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Cerebrospinal fluid corticotropin-releasing hormone in depression: Relationship to noradrenergic function

Abstract

Keywords

ASJC Scopus subject areas

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