Cerebrospinal fluid corticotropin-releasing hormone in depression: Relationship to noradrenergic function

Alec Roy, David Pickar, Markku Linnoila, George P. Chrousos, Philip W. Gold

Research output: Contribution to journalArticle


We investigated the neurotransmitter regulation of corticotropin-releasing hormone (CRH). Among 21 depressed patients cerebrospinal fluid (CSF) levels of CRH significantly correlated with urinary outputs of norepinephrine and its major metabolites, and there were trends for significant correlations with both CSF and plasma levels of norepinephrine. These results suggest that CRH may be associated with the dysregulation of the norepinephrine system that is found in desperation.

Original languageEnglish (US)
Pages (from-to)229-237
Number of pages9
JournalPsychiatry Research
Issue number3
StatePublished - 1987
Externally publishedYes



  • Corticotropin-releasing hormone
  • depression
  • norepinephrine

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

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