Cerebrospinal fluid Coccidioides antigen testing in the diagnosis and management of central nervous system coccidioidomycosis

David M. Bamberger, Brian S. Pepito, Laurie A. Proia, Luis Ostrosky-Zeichner, Madiha Ashraf, Francisco Marty, Eileen Scully, L. Joseph Wheat

Research output: Contribution to journalArticlepeer-review

Abstract

The goal of this study was to report on the potential utility of cerebrospinal fluid (CSF) Coccidioides antigen testing in the diagnosis and management of Coccidioides meningitis. We retrospectively reviewed medical records of seven patients with Coccidioides meningitis who had Coccidioides antigen tests performed on CSF. In two severely immunocompromised patients, CSF Coccidioides antigen testing was helpful in the diagnosis when other testing modalities were negative. Coccidioides antigen testing was also useful in the management of patients who had progression of disease due to non-adherence, development of resistance, failure of therapy and the presence of vasculitis. Changing antigen levels helped identify disease complications in three patients that led to alterations in therapy or management. On the basis of our review of these seven patients with Coccidioides meningitis, we concluded that the Coccidioides antigen test contributed to the diagnosis and management of patients with Coccidioides meningitis.

Original languageEnglish (US)
Pages (from-to)598-602
Number of pages5
JournalMycoses
Volume58
Issue number10
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Keywords

  • Antigen
  • Cerebrospinal fluid
  • Coccidioides
  • Coccidioidomycosis
  • Meningitis

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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