Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, tourette’s syndrome, and healthy controls

James F. Leckman, Wayne K. Goodman, George M. Anderson, Mark A Riddle, Phillip B. Chappell, Maureen T. McSwiggan-Hardin, Christopher J. McDougle, Lawrence D. Scahill, Sharon I. Ort, David L. Pauls, Donald J. Cohen, Lawrence H. Price

Research output: Contribution to journalArticle

Abstract

To examine the role of noradrenergic, dopaminergic, and serotonergic mechanisms in the pathobiology of obsessive compulsive disorder (OCD) and Tourette's syndrome (TS), concentrations of tyrosine (TYR), norepinephrine (NE), 3-methoxy-4-hydroxyphenylethylene glycol (MHPG), homovanillic acid (HVA), tryptophan (TRP), and 5-hydroxyindoleacetic acid (5-HIAA) were measured in the lumbar cerebrospinal fluid (CSF) of 39 medication- free OCD patients, 33 medication-free TS patients, and 44 healthy volunteers. CSF TYR concentrations were reduced (p

Original languageEnglish (US)
Pages (from-to)73-86
Number of pages14
JournalNeuropsychopharmacology
Volume12
Issue number1
DOIs
StatePublished - 1995

Keywords

  • 3-methoxy-4- hydroxyphenylethylene glycol
  • 5-hydroxyindoleacetic acid
  • CSF
  • Homovanillic acid
  • Norepinephrine
  • Obsessive compulsive disorder
  • Tourette's syndrome
  • Tryptophan
  • Tyrosine

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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  • Cite this

    Leckman, J. F., Goodman, W. K., Anderson, G. M., Riddle, M. A., Chappell, P. B., McSwiggan-Hardin, M. T., McDougle, C. J., Scahill, L. D., Ort, S. I., Pauls, D. L., Cohen, D. J., & Price, L. H. (1995). Cerebrospinal fluid biogenic amines in obsessive compulsive disorder, tourette’s syndrome, and healthy controls. Neuropsychopharmacology, 12(1), 73-86. https://doi.org/10.1038/sj.npp.1380241