Cerebrospinal fluid amyloid β40 is decreased in cerebral amyloid angiopathy

Marcel M. Verbeek, Berry P.H. Kremer, Marcel Olde Rikkert, Peter H.M.F. Van Domburg, Maureen E. Skehan, Steven M. Greenberg

Research output: Contribution to journalArticlepeer-review


Cerebral amyloid angiopathy is caused by deposition of the amyloid β protein in the cerebral vasculature. In analogy to previous observations in Alzheimer disease, we hypothesized that analysis of amyloid β40 and β42 proteins in the cerebrospinal fluid might serve as a molecular biomarker. We observed strongly decreased cerebrospinal fluid amyloid β40 (p < 0.01 vs controls or Alzheimer disease) and amyloid β42 concentrations (p < 0.001 vs controls and p < 0.05 vs Alzheimer disease) in cerebral amyloid angiopathy patients. The combination of amyloid β42 and total tau discriminated cerebral amyloid angiopathy from controls, with an area under the receiver operator curve of 0.98. Our data are consistent with neuropathological evidence that amyloid β40 as well as amyloid β42 protein are selectively trapped in the cerebral vasculature from interstitial fluid drainage pathways that otherwise transport amyloid β proteins toward the cerebrospinal fluid.

Original languageEnglish (US)
Pages (from-to)245-249
Number of pages5
JournalAnnals of neurology
Issue number2
StatePublished - Aug 2009
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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