Cerebrospinal fluid acetylcholinesterase activity in senile dementia of the Alzheimer type

L. Tune, S. Gucker, Marshal F. Folstein, L. Oshida, J. T. Coyle

Research output: Contribution to journalArticle

Abstract

Acetylcholinesterase (AChE) activity was measured in cerebrospinal fluid (CSF) samples from 36 individuals, including 12 persons with Alzheimer's disease, 12 normal controls, and 12 patients with other dementias. AChE activity also was measured in 47 normal subjects whose ages ranged from 20 to 84 to evaluate the effect of age on AChE activity. CSF from patients with senile dementia of the Alzheimer type showed significantly lower mean AChE activity than in age-matched controls and patients with other dementia syndromes. No correlation was found between duration of illness, age, or severity of illness (as measured by the Mini-Mental State Examination score) and CSF AChE activity in Alzheimer's disease. AChE increased significantly over the age range of 20 to 84. CSF AChE activity may prove to be a useful diagnostic test to confirm the clinical diagnosis of moderate to severe Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)46-48
Number of pages3
JournalAnnals of Neurology
Volume17
Issue number1
DOIs
StatePublished - 1985

Fingerprint

Acetylcholinesterase
Cerebrospinal Fluid
Alzheimer Disease
Dementia
Routine Diagnostic Tests

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cerebrospinal fluid acetylcholinesterase activity in senile dementia of the Alzheimer type. / Tune, L.; Gucker, S.; Folstein, Marshal F.; Oshida, L.; Coyle, J. T.

In: Annals of Neurology, Vol. 17, No. 1, 1985, p. 46-48.

Research output: Contribution to journalArticle

Tune, L. ; Gucker, S. ; Folstein, Marshal F. ; Oshida, L. ; Coyle, J. T. / Cerebrospinal fluid acetylcholinesterase activity in senile dementia of the Alzheimer type. In: Annals of Neurology. 1985 ; Vol. 17, No. 1. pp. 46-48.
@article{34e2af4922b24c80b6ac05813432f638,
title = "Cerebrospinal fluid acetylcholinesterase activity in senile dementia of the Alzheimer type",
abstract = "Acetylcholinesterase (AChE) activity was measured in cerebrospinal fluid (CSF) samples from 36 individuals, including 12 persons with Alzheimer's disease, 12 normal controls, and 12 patients with other dementias. AChE activity also was measured in 47 normal subjects whose ages ranged from 20 to 84 to evaluate the effect of age on AChE activity. CSF from patients with senile dementia of the Alzheimer type showed significantly lower mean AChE activity than in age-matched controls and patients with other dementia syndromes. No correlation was found between duration of illness, age, or severity of illness (as measured by the Mini-Mental State Examination score) and CSF AChE activity in Alzheimer's disease. AChE increased significantly over the age range of 20 to 84. CSF AChE activity may prove to be a useful diagnostic test to confirm the clinical diagnosis of moderate to severe Alzheimer's disease.",
author = "L. Tune and S. Gucker and Folstein, {Marshal F.} and L. Oshida and Coyle, {J. T.}",
year = "1985",
doi = "10.1002/ana.410170111",
language = "English (US)",
volume = "17",
pages = "46--48",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Cerebrospinal fluid acetylcholinesterase activity in senile dementia of the Alzheimer type

AU - Tune, L.

AU - Gucker, S.

AU - Folstein, Marshal F.

AU - Oshida, L.

AU - Coyle, J. T.

PY - 1985

Y1 - 1985

N2 - Acetylcholinesterase (AChE) activity was measured in cerebrospinal fluid (CSF) samples from 36 individuals, including 12 persons with Alzheimer's disease, 12 normal controls, and 12 patients with other dementias. AChE activity also was measured in 47 normal subjects whose ages ranged from 20 to 84 to evaluate the effect of age on AChE activity. CSF from patients with senile dementia of the Alzheimer type showed significantly lower mean AChE activity than in age-matched controls and patients with other dementia syndromes. No correlation was found between duration of illness, age, or severity of illness (as measured by the Mini-Mental State Examination score) and CSF AChE activity in Alzheimer's disease. AChE increased significantly over the age range of 20 to 84. CSF AChE activity may prove to be a useful diagnostic test to confirm the clinical diagnosis of moderate to severe Alzheimer's disease.

AB - Acetylcholinesterase (AChE) activity was measured in cerebrospinal fluid (CSF) samples from 36 individuals, including 12 persons with Alzheimer's disease, 12 normal controls, and 12 patients with other dementias. AChE activity also was measured in 47 normal subjects whose ages ranged from 20 to 84 to evaluate the effect of age on AChE activity. CSF from patients with senile dementia of the Alzheimer type showed significantly lower mean AChE activity than in age-matched controls and patients with other dementia syndromes. No correlation was found between duration of illness, age, or severity of illness (as measured by the Mini-Mental State Examination score) and CSF AChE activity in Alzheimer's disease. AChE increased significantly over the age range of 20 to 84. CSF AChE activity may prove to be a useful diagnostic test to confirm the clinical diagnosis of moderate to severe Alzheimer's disease.

UR - http://www.scopus.com/inward/record.url?scp=0022002826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022002826&partnerID=8YFLogxK

U2 - 10.1002/ana.410170111

DO - 10.1002/ana.410170111

M3 - Article

C2 - 3985585

AN - SCOPUS:0022002826

VL - 17

SP - 46

EP - 48

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 1

ER -