TY - JOUR
T1 - Cerebral Single-Photon Emission Computed Tomography Abnormalities in Human Immunodeficiency Virus Type 1-Infected Gay Men Without Cognitive Impairment
AU - Sacktor, Ned
AU - Dooneief, George
AU - Marder, Karen
AU - Stern, Yaakov
AU - Mayeux, Richard
AU - Prohovnik, Isak
AU - Van Heertum, Ronald L.
AU - Gorman, Jack
AU - Todak, George
PY - 1995/6
Y1 - 1995/6
N2 - To determine whether technetium Tc 99m exametazime single-photon computed emission tomography (SPECT) can distinguish gay human immunodeficiency virus (HIV)—positive subjects, both with and without mild cognitive impairment, from gay HIV-negative control subjects. Twenty HIV-positive subjects (12 without cognitive impairment and eight with mild cognitive impairment) and 10 HIV-negative subjects underwent neurological, neuropsychological, magnetic resonance imaging, and technetium Tc 99m exametazime SPECT examinations. Subjects were recruited from a natural history study of gay men with HIV infection. Subjects from the cohort who had previously participated in a magnetic resonance imaging study were selected for the SPECT study. The SPECT scans were rated as abnormal if focal defects, confirmed by a horizontal profile analysis, were seen. Sixty-seven percent of HIV-positive subjects without cognitive impairment, 88% of HIV-positive subjects with mild cognitive impairment, and 20% of HIV-negative subjects had abnormal SPECT scans (P<.05 for both HIV-positive groups when each group was compared with HIV-negative subjects). Compared with gay HIV-negative control subjects, focal SPECT defects are seen with an increased frequency in HIV-positive gay men without cognitive impairment and in HIV-positive gay men with mild cognitive impairment.
AB - To determine whether technetium Tc 99m exametazime single-photon computed emission tomography (SPECT) can distinguish gay human immunodeficiency virus (HIV)—positive subjects, both with and without mild cognitive impairment, from gay HIV-negative control subjects. Twenty HIV-positive subjects (12 without cognitive impairment and eight with mild cognitive impairment) and 10 HIV-negative subjects underwent neurological, neuropsychological, magnetic resonance imaging, and technetium Tc 99m exametazime SPECT examinations. Subjects were recruited from a natural history study of gay men with HIV infection. Subjects from the cohort who had previously participated in a magnetic resonance imaging study were selected for the SPECT study. The SPECT scans were rated as abnormal if focal defects, confirmed by a horizontal profile analysis, were seen. Sixty-seven percent of HIV-positive subjects without cognitive impairment, 88% of HIV-positive subjects with mild cognitive impairment, and 20% of HIV-negative subjects had abnormal SPECT scans (P<.05 for both HIV-positive groups when each group was compared with HIV-negative subjects). Compared with gay HIV-negative control subjects, focal SPECT defects are seen with an increased frequency in HIV-positive gay men without cognitive impairment and in HIV-positive gay men with mild cognitive impairment.
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U2 - 10.1001/archneur.1995.00540300081017
DO - 10.1001/archneur.1995.00540300081017
M3 - Article
C2 - 7763210
AN - SCOPUS:0029009808
SN - 0003-9942
VL - 52
SP - 607
EP - 611
JO - Archives of neurology
JF - Archives of neurology
IS - 6
ER -