Cerebral perfusion alterations in epileptic patients during peri-ictal and post-ictal phase

PASL vs DSC-MRI

Francesca B. Pizzini, Paolo Farace, Paolo Manganotti, Giada Zoccatelli, Luigi G. Bongiovanni, Xavier Golay, Alberto Beltramello, Antonio Osculati, Giuseppe Bertini, Paolo F. Fabene

Research output: Contribution to journalArticle

Abstract

Non-invasive pulsed arterial spin labeling (PASL) MRI is a method to study brain perfusion that does not require the administration of a contrast agent, which makes it a valuable diagnostic tool as it reduces cost and side effects. The purpose of the present study was to establish the viability of PASL as an alternative to dynamic susceptibility contrast (DSC-MRI) and other perfusion imaging methods in characterizing changes in perfusion patterns caused by seizures in epileptic patients. We evaluated 19 patients with PASL. Of these, the 9 affected by high-frequency seizures were observed during the peri-ictal period (within 5. hours since the last seizure), while the 10 patients affected by low-frequency seizures were observed in the post-ictal period. For comparison, 17/19 patients were also evaluated with DSC-MRI and CBF/CBV. PASL imaging showed focal vascular changes, which allowed the classification of patients in three categories: 8 patients characterized by increased perfusion, 4 patients with normal perfusion and 7 patients with decreased perfusion. PASL perfusion imaging findings were comparable to those obtained by DSC-MRI. Since PASL is a) sensitive to vascular alterations induced by epileptic seizures, b) comparable to DSC-MRI for detecting perfusion asymmetries, c) potentially capable of detecting time-related perfusion changes, it can be recommended for repeated evaluations, to identify the epileptic focus, and in follow-up and/or therapy-response assessment.

Original languageEnglish (US)
Pages (from-to)1001-1005
Number of pages5
JournalMagnetic Resonance Imaging
Volume31
Issue number6
DOIs
StatePublished - Jul 2013
Externally publishedYes

Fingerprint

Magnetic resonance imaging
Labeling
Perfusion
Stroke
Imaging techniques
Seizures
Perfusion Imaging
Blood Vessels
Epilepsy
Brain
Contrast Media
Costs and Cost Analysis
Costs

Keywords

  • Arterial spin labeling
  • Epilepsy
  • Hyperperfusion
  • Hypoperfusion
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Biomedical Engineering

Cite this

Pizzini, F. B., Farace, P., Manganotti, P., Zoccatelli, G., Bongiovanni, L. G., Golay, X., ... Fabene, P. F. (2013). Cerebral perfusion alterations in epileptic patients during peri-ictal and post-ictal phase: PASL vs DSC-MRI. Magnetic Resonance Imaging, 31(6), 1001-1005. https://doi.org/10.1016/j.mri.2013.03.023

Cerebral perfusion alterations in epileptic patients during peri-ictal and post-ictal phase : PASL vs DSC-MRI. / Pizzini, Francesca B.; Farace, Paolo; Manganotti, Paolo; Zoccatelli, Giada; Bongiovanni, Luigi G.; Golay, Xavier; Beltramello, Alberto; Osculati, Antonio; Bertini, Giuseppe; Fabene, Paolo F.

In: Magnetic Resonance Imaging, Vol. 31, No. 6, 07.2013, p. 1001-1005.

Research output: Contribution to journalArticle

Pizzini, FB, Farace, P, Manganotti, P, Zoccatelli, G, Bongiovanni, LG, Golay, X, Beltramello, A, Osculati, A, Bertini, G & Fabene, PF 2013, 'Cerebral perfusion alterations in epileptic patients during peri-ictal and post-ictal phase: PASL vs DSC-MRI', Magnetic Resonance Imaging, vol. 31, no. 6, pp. 1001-1005. https://doi.org/10.1016/j.mri.2013.03.023
Pizzini, Francesca B. ; Farace, Paolo ; Manganotti, Paolo ; Zoccatelli, Giada ; Bongiovanni, Luigi G. ; Golay, Xavier ; Beltramello, Alberto ; Osculati, Antonio ; Bertini, Giuseppe ; Fabene, Paolo F. / Cerebral perfusion alterations in epileptic patients during peri-ictal and post-ictal phase : PASL vs DSC-MRI. In: Magnetic Resonance Imaging. 2013 ; Vol. 31, No. 6. pp. 1001-1005.
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