Cerebral oxygen metabolism in patients with early Parkinson's disease

Per Borghammer, Paul Cumming, Karen Estergaard, Albert Gjedde, Anders Rodell, Christopher J. Bailey, Manoucher S. Vafaee

Research output: Contribution to journalArticle

Abstract

Aim: Decreased activity of the mitochondrial electron transport chain (ETC) has been implicated in the pathogenesis of Parkinson's disease (PD). This model would most likely predict a decrease in the rate of cerebral oxygen consumption (CMRO2). To test this hypothesis, we compared CMRO2 and cerebral blood flow (CBF) PET scans from PD patients and healthy controls. Materials and methods: Nine early-stage PD patients and 15 healthy age-matched controls underwent PET scans for quantitative mapping of CMRO2 and CBF. Between-group differences were evaluated for absolute data and intensity-normalized values. Results: No group differences were detected in regional magnitudes of CMRO2 or CBF. Upon normalization using the reference cluster method, significant relative CMRO2 decreases were evident in widespread prefrontal, parieto-occipital, and lateral temporal regions. Sensory-motor and subcortical regions, brainstem, and the cerebellum were spared. A similar pattern was evident in normalized CBF data, as described previously. Conclusion: While the data did not reveal substantially altered absolute CMRO2 in brain of PD patients, employing data-driven intensity normalization revealed widespread relative CMRO2 decreases in cerebral cortex. The detected pattern was very similar to that reported in earlier CBF and CMRglc studies of PD, and in the CBF images from the same subjects. Thus, the present results are consistent with the occurrence of parallel declines in CMRO2, CBF, and CMRglc in spatially contiguous cortical regions in early PD, and support the hypothesis that ETC dysfunction could be a primary pathogenic mechanism in early PD.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalJournal of the Neurological Sciences
Volume313
Issue number1-2
DOIs
StatePublished - Feb 15 2012
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Parkinson Disease
Oxygen
Electron Transport
Positron-Emission Tomography
Brain Diseases
Temporal Lobe
Oxygen Consumption
Cerebral Cortex
Cerebellum
Brain Stem

Keywords

  • CBF
  • CMRO
  • Energy metabolism
  • Normalization
  • Oxygen
  • Parkinson's disease
  • Positron emission tomography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Borghammer, P., Cumming, P., Estergaard, K., Gjedde, A., Rodell, A., Bailey, C. J., & Vafaee, M. S. (2012). Cerebral oxygen metabolism in patients with early Parkinson's disease. Journal of the Neurological Sciences, 313(1-2), 123-128. https://doi.org/10.1016/j.jns.2011.09.010

Cerebral oxygen metabolism in patients with early Parkinson's disease. / Borghammer, Per; Cumming, Paul; Estergaard, Karen; Gjedde, Albert; Rodell, Anders; Bailey, Christopher J.; Vafaee, Manoucher S.

In: Journal of the Neurological Sciences, Vol. 313, No. 1-2, 15.02.2012, p. 123-128.

Research output: Contribution to journalArticle

Borghammer, P, Cumming, P, Estergaard, K, Gjedde, A, Rodell, A, Bailey, CJ & Vafaee, MS 2012, 'Cerebral oxygen metabolism in patients with early Parkinson's disease', Journal of the Neurological Sciences, vol. 313, no. 1-2, pp. 123-128. https://doi.org/10.1016/j.jns.2011.09.010
Borghammer P, Cumming P, Estergaard K, Gjedde A, Rodell A, Bailey CJ et al. Cerebral oxygen metabolism in patients with early Parkinson's disease. Journal of the Neurological Sciences. 2012 Feb 15;313(1-2):123-128. https://doi.org/10.1016/j.jns.2011.09.010
Borghammer, Per ; Cumming, Paul ; Estergaard, Karen ; Gjedde, Albert ; Rodell, Anders ; Bailey, Christopher J. ; Vafaee, Manoucher S. / Cerebral oxygen metabolism in patients with early Parkinson's disease. In: Journal of the Neurological Sciences. 2012 ; Vol. 313, No. 1-2. pp. 123-128.
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