Cerebral metabolism and blood flow after circulatory arrest during deep hypothermia

A. M. Perna, T. J. Gardner, K. Tabaddor, Robert K. Brawley, Vincent L Gott

Research output: Contribution to journalArticle

Abstract

Cerebral metabolic activity was measured in ten dogs undergoing deep hypothermia and circulatory arrest for 45 minutes using a method of surface induced cooling, ether anesthesia, and hyperventilation. Cerebral blood flow and cerebral oxygen consumption were measured utilizing a mass spectrometer by the inert gas technic. Cerebral oxygen consumption at the completion of circulatory arrest and rewarming increased 15% over the mean pre cooling rate of oxygen consumption, indicating a restoration of adequate cerebral metabolic activity. A mean decrease in the cerebral blood flow of 18% and an increase of cerebral vascular resistance of 8% in the post arrest state was found, suggesting mild cerebral vascular damage. Direct and continuous measurements of the cerebral cortical PCO 2 and PCO 2 levels during the 45 minutes of circulatory arrest in five animals indicate continuing cerebral metabolic activity during the arrest period, with brain oxygen utilization ceasing after the first 15 minutes of the arrest period. Despite the marked lowering of the blood PCO 2 levels in the animals at deep hypothermic levels as a result of the hyperventilation, there was no evidence of an increase in cerebral vascular resistance. Using the technic of surface induced hypothermia with ether anesthesia and hyperventilation, circulatory arrest for 45 minutes at 18 C was tolerated by the animals without evidence of impairment of cerebral metabolism, despite a consistent reduction in cerebral blood flow.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalAnnals of Surgery
Volume178
Issue number1
StatePublished - 1973
Externally publishedYes

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Cerebrovascular Circulation
Hyperventilation
Hypothermia
Oxygen Consumption
Vascular Resistance
Ether
Anesthesia
Noble Gases
Induced Hypothermia
Rewarming
Blood Vessels
Dogs
Oxygen
Brain

ASJC Scopus subject areas

  • Surgery

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Cerebral metabolism and blood flow after circulatory arrest during deep hypothermia. / Perna, A. M.; Gardner, T. J.; Tabaddor, K.; Brawley, Robert K.; Gott, Vincent L.

In: Annals of Surgery, Vol. 178, No. 1, 1973, p. 95-101.

Research output: Contribution to journalArticle

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