TY - JOUR
T1 - Cerebral ischemia mediates the effect of serum uric acid on cognitive function
AU - Vannorsdall, Tracy D.
AU - Jinnah, H. A.
AU - Gordon, Barry
AU - Kraut, Michael
AU - Schretlen, David J.
N1 - Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2008/12/1
Y1 - 2008/12/1
N2 - Background and Purpose: High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes. We hypothesized that individual differences in white matter hyperintensities mediate the association between UA and mild cognitive dysfunction. Methods: One hundred eighty community-dwelling adults aged 20 to 96 years completed neuropsychological testing, laboratory blood studies, and a brain MRI scan. Results: Serum UA was associated (P<0.05) with greater white matter hyperintensities and poorer working memory, processing speed, fluency, and verbal memory. Associations remained after controlling for age, sex, race, education, hypertension, diabetes, alcohol abuse, smoking, and body mass. Adding a term for white matter hyperintensity attenuated these associations such that UA no longer predicted cognitive performance. Conclusions: Severity of cerebral ischemia might mediate the association between UA and cognitive dysfunction. Even mild elevations in UA appear to contribute to structural and functional brain changes.
AB - Background and Purpose: High normal concentrations of serum uric acid (UA) are associated with mild cognitive dysfunction and increased cerebral ischemia as indexed by white matter hyperintensity volumes. We hypothesized that individual differences in white matter hyperintensities mediate the association between UA and mild cognitive dysfunction. Methods: One hundred eighty community-dwelling adults aged 20 to 96 years completed neuropsychological testing, laboratory blood studies, and a brain MRI scan. Results: Serum UA was associated (P<0.05) with greater white matter hyperintensities and poorer working memory, processing speed, fluency, and verbal memory. Associations remained after controlling for age, sex, race, education, hypertension, diabetes, alcohol abuse, smoking, and body mass. Adding a term for white matter hyperintensity attenuated these associations such that UA no longer predicted cognitive performance. Conclusions: Severity of cerebral ischemia might mediate the association between UA and cognitive dysfunction. Even mild elevations in UA appear to contribute to structural and functional brain changes.
KW - Aging
KW - Brain ischemia
KW - Cognitive impairment
KW - Neuropsychology
KW - Uric acid
KW - White matter disease
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U2 - 10.1161/STROKEAHA.108.521591
DO - 10.1161/STROKEAHA.108.521591
M3 - Article
C2 - 18772442
AN - SCOPUS:58149333279
VL - 39
SP - 3418
EP - 3420
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 12
ER -