Cerebral glucose utilization in polysubstance abuse

June M. Stapleton, Michael J. Morgan, Robert L. Phillips, Dean Foster Wong, Babington C K Yung, Elias K. Shaya, Robert F Dannals, Xiang Liu, Roger L. Grayson, Edythe D. London

Research output: Contribution to journalArticle

Abstract

Regional cerebral glucose metabolism in subjects with histories of polysubstance abuse was compared to that in control subjects who were drawn from the same community. The substance abuse group showed lower absolute metabolic rates for glucose in lateral occipital gyrus and higher normalized metabolic rates in temporal and frontal areas, including orbitofrontal cortex. It is suggested that some patterns of brain function associated with polysubstance abuse may represent consequences of drug exposure, or they could reflect pre-existing differences that may be relevant to the etiology and maintenance of polysubstance abuse.

Original languageEnglish (US)
Pages (from-to)21-31
Number of pages11
JournalNeuropsychopharmacology
Volume13
Issue number1
DOIs
StatePublished - 1995

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Glucose
Occipital Lobe
Prefrontal Cortex
Substance-Related Disorders
Maintenance
Brain
Pharmaceutical Preparations

Keywords

  • Brain imaging
  • Cerebral glucose metabolism
  • Drug abuse
  • Fluorodeoxyglucose
  • Positron emission tomography
  • Substance abuse

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology

Cite this

Stapleton, J. M., Morgan, M. J., Phillips, R. L., Wong, D. F., Yung, B. C. K., Shaya, E. K., ... London, E. D. (1995). Cerebral glucose utilization in polysubstance abuse. Neuropsychopharmacology, 13(1), 21-31. https://doi.org/10.1016/0893-133X(94)00132-J

Cerebral glucose utilization in polysubstance abuse. / Stapleton, June M.; Morgan, Michael J.; Phillips, Robert L.; Wong, Dean Foster; Yung, Babington C K; Shaya, Elias K.; Dannals, Robert F; Liu, Xiang; Grayson, Roger L.; London, Edythe D.

In: Neuropsychopharmacology, Vol. 13, No. 1, 1995, p. 21-31.

Research output: Contribution to journalArticle

Stapleton, JM, Morgan, MJ, Phillips, RL, Wong, DF, Yung, BCK, Shaya, EK, Dannals, RF, Liu, X, Grayson, RL & London, ED 1995, 'Cerebral glucose utilization in polysubstance abuse', Neuropsychopharmacology, vol. 13, no. 1, pp. 21-31. https://doi.org/10.1016/0893-133X(94)00132-J
Stapleton JM, Morgan MJ, Phillips RL, Wong DF, Yung BCK, Shaya EK et al. Cerebral glucose utilization in polysubstance abuse. Neuropsychopharmacology. 1995;13(1):21-31. https://doi.org/10.1016/0893-133X(94)00132-J
Stapleton, June M. ; Morgan, Michael J. ; Phillips, Robert L. ; Wong, Dean Foster ; Yung, Babington C K ; Shaya, Elias K. ; Dannals, Robert F ; Liu, Xiang ; Grayson, Roger L. ; London, Edythe D. / Cerebral glucose utilization in polysubstance abuse. In: Neuropsychopharmacology. 1995 ; Vol. 13, No. 1. pp. 21-31.
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