Regional and global cerebral metabolic rates for glucose (rCMRglu, CMRglu) were assayed in two active heroin addicts and three post-addicts by the [18F]fluorodeoxyglucose (FDG) positron emission tomographic (PET) method. Self-reports on the Morphine-Benzedrine Group (MBG) scale of the Addiction Research Center Inventory (ARCI) indicated no effect of heroin on mood in subject #1, but a strong effect in subject #2. Compared with postaddicts, subject #1 showed fewer differences in rCMRglu than subject #2. Metabolic rates in subject #1 were lower in the cuneus, gyrus rectus, and cerebellum, but higher in the amygdala-hippocampus than in postaddicts; CMRglu was not changed. Subject #2 showed lower CMRglu and rCMRglu in areas of visual cortex, the basal ganglia and hippocampal formation. The findings suggest that chronic heroin can produce persistent deficits in telencephalic rCMRglu, which may relate to effects on mood.
|Original language||English (US)|
|Number of pages||4|
|Journal||Research Communications in Substances of Abuse|
|State||Published - 1989|
ASJC Scopus subject areas
- Medicine (miscellaneous)