Cerebral Edema: Role of Fatty Acid Metabolism of Brain Capillaries

Gary W. Goldstein, Kay Tanaka

Research output: Contribution to journalLetter


To the Editor: Jamaican vomiting sickness and Reye's syndrome are characterized by profound brain edema and coma. Tanaka et al. have confirmed the presence of hypoglycin in patients with Jamaican vomiting sickness (N Engl J Med 295:461, 1976), and Trauner and Nyhan have suggested that the resulting increase in serum fatty acids resembles that seen in Reye's syndrome (N Engl J Med 295:1481, 1976). However, neither the hypoglycemia nor the moderate increase in serum fatty acid levels that occur in both conditions appears to provide an adequate explanation for the devastating neurologic symptoms, as indicated by Dr. Tanaka (N.

Original languageEnglish (US)
Pages (from-to)632-633
Number of pages2
JournalNew England Journal of Medicine
Issue number11
StatePublished - Mar 17 1977

ASJC Scopus subject areas

  • Medicine(all)

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