Cerebral blood volume mapping using Fourier-transform–based velocity-selective saturation pulse trains

Qin Qin, Yaoming Qu, Wenbo Li, Dapeng Liu, Taehoon Shin, Yansong Zhao, Doris Lin, Peter C Van Zijl, Zhibo Wen

Research output: Contribution to journalArticle

Abstract

Purpose: Velocity-selective saturation (VSS) pulse trains provide a viable alternative to the spatially selective methods for measuring cerebral blood volume (CBV) by reducing the sensitivity to arterial transit time. This study is to compare the Fourier-transform–based velocity-selective saturation (FT-VSS) pulse trains with the conventional flow-dephasing VSS techniques for CBV quantification. Methods: The proposed FT-VSS label and control modules were compared with VSS pulse trains utilizing double refocused hyperbolic tangent (DRHT) and 8-segment B1-insensitive rotation (BIR-8). This was done using both numerical simulations and phantom studies to evaluate their sensitivities to gradient imperfections such as eddy currents. DRHT, BIR-8, and FT-VSS prepared CBV mapping was further compared for velocity-encoding gradients along 3 orthogonal directions in healthy subjects at 3T. Results: The phantom studies exhibited more consistent immunity to gradient imperfections for the utilized FT-VSS pulse trains. Compared to DRHT and BIR-8, FT-VSS delivered more robust CBV results across the 3 VS encoding directions with significantly reduced artifacts along the superior-inferior direction and improved temporal signal-to-noise ratio (SNR) values. Average CBV values obtained from FT-VSS based sequences were 5.3 mL/100 g for gray matter and 2.3 mL/100 g for white matter, comparable to literature expectations. Conclusion: Absolute CBV quantification utilizing advanced FT-VSS pulse trains had several advantages over the existing approaches using flow-dephasing VSS modules. A greater immunity to gradient imperfections and the concurrent tissue background suppression of FT-VSS pulse trains enabled more robust CBV measurements and higher SNR than the conventional VSS pulse trains.

Original languageEnglish (US)
JournalMagnetic resonance in medicine
DOIs
StatePublished - Jan 1 2019

Fingerprint

Signal-To-Noise Ratio
Immunity
Cerebral Blood Volume
Artifacts
Healthy Volunteers
Direction compound
White Matter
Gray Matter

Keywords

  • arterial spin labeling
  • cerebral blood volume
  • eddy current
  • Fourier-transform–based velocity-selective saturation
  • velocity-selective pulse train

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Cerebral blood volume mapping using Fourier-transform–based velocity-selective saturation pulse trains. / Qin, Qin; Qu, Yaoming; Li, Wenbo; Liu, Dapeng; Shin, Taehoon; Zhao, Yansong; Lin, Doris; Van Zijl, Peter C; Wen, Zhibo.

In: Magnetic resonance in medicine, 01.01.2019.

Research output: Contribution to journalArticle

@article{a79c05faf11d4f45b8506ab2c9d80369,
title = "Cerebral blood volume mapping using Fourier-transform–based velocity-selective saturation pulse trains",
abstract = "Purpose: Velocity-selective saturation (VSS) pulse trains provide a viable alternative to the spatially selective methods for measuring cerebral blood volume (CBV) by reducing the sensitivity to arterial transit time. This study is to compare the Fourier-transform–based velocity-selective saturation (FT-VSS) pulse trains with the conventional flow-dephasing VSS techniques for CBV quantification. Methods: The proposed FT-VSS label and control modules were compared with VSS pulse trains utilizing double refocused hyperbolic tangent (DRHT) and 8-segment B1-insensitive rotation (BIR-8). This was done using both numerical simulations and phantom studies to evaluate their sensitivities to gradient imperfections such as eddy currents. DRHT, BIR-8, and FT-VSS prepared CBV mapping was further compared for velocity-encoding gradients along 3 orthogonal directions in healthy subjects at 3T. Results: The phantom studies exhibited more consistent immunity to gradient imperfections for the utilized FT-VSS pulse trains. Compared to DRHT and BIR-8, FT-VSS delivered more robust CBV results across the 3 VS encoding directions with significantly reduced artifacts along the superior-inferior direction and improved temporal signal-to-noise ratio (SNR) values. Average CBV values obtained from FT-VSS based sequences were 5.3 mL/100 g for gray matter and 2.3 mL/100 g for white matter, comparable to literature expectations. Conclusion: Absolute CBV quantification utilizing advanced FT-VSS pulse trains had several advantages over the existing approaches using flow-dephasing VSS modules. A greater immunity to gradient imperfections and the concurrent tissue background suppression of FT-VSS pulse trains enabled more robust CBV measurements and higher SNR than the conventional VSS pulse trains.",
keywords = "arterial spin labeling, cerebral blood volume, eddy current, Fourier-transform–based velocity-selective saturation, velocity-selective pulse train",
author = "Qin Qin and Yaoming Qu and Wenbo Li and Dapeng Liu and Taehoon Shin and Yansong Zhao and Doris Lin and {Van Zijl}, {Peter C} and Zhibo Wen",
year = "2019",
month = "1",
day = "1",
doi = "10.1002/mrm.27668",
language = "English (US)",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",

}

TY - JOUR

T1 - Cerebral blood volume mapping using Fourier-transform–based velocity-selective saturation pulse trains

AU - Qin, Qin

AU - Qu, Yaoming

AU - Li, Wenbo

AU - Liu, Dapeng

AU - Shin, Taehoon

AU - Zhao, Yansong

AU - Lin, Doris

AU - Van Zijl, Peter C

AU - Wen, Zhibo

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: Velocity-selective saturation (VSS) pulse trains provide a viable alternative to the spatially selective methods for measuring cerebral blood volume (CBV) by reducing the sensitivity to arterial transit time. This study is to compare the Fourier-transform–based velocity-selective saturation (FT-VSS) pulse trains with the conventional flow-dephasing VSS techniques for CBV quantification. Methods: The proposed FT-VSS label and control modules were compared with VSS pulse trains utilizing double refocused hyperbolic tangent (DRHT) and 8-segment B1-insensitive rotation (BIR-8). This was done using both numerical simulations and phantom studies to evaluate their sensitivities to gradient imperfections such as eddy currents. DRHT, BIR-8, and FT-VSS prepared CBV mapping was further compared for velocity-encoding gradients along 3 orthogonal directions in healthy subjects at 3T. Results: The phantom studies exhibited more consistent immunity to gradient imperfections for the utilized FT-VSS pulse trains. Compared to DRHT and BIR-8, FT-VSS delivered more robust CBV results across the 3 VS encoding directions with significantly reduced artifacts along the superior-inferior direction and improved temporal signal-to-noise ratio (SNR) values. Average CBV values obtained from FT-VSS based sequences were 5.3 mL/100 g for gray matter and 2.3 mL/100 g for white matter, comparable to literature expectations. Conclusion: Absolute CBV quantification utilizing advanced FT-VSS pulse trains had several advantages over the existing approaches using flow-dephasing VSS modules. A greater immunity to gradient imperfections and the concurrent tissue background suppression of FT-VSS pulse trains enabled more robust CBV measurements and higher SNR than the conventional VSS pulse trains.

AB - Purpose: Velocity-selective saturation (VSS) pulse trains provide a viable alternative to the spatially selective methods for measuring cerebral blood volume (CBV) by reducing the sensitivity to arterial transit time. This study is to compare the Fourier-transform–based velocity-selective saturation (FT-VSS) pulse trains with the conventional flow-dephasing VSS techniques for CBV quantification. Methods: The proposed FT-VSS label and control modules were compared with VSS pulse trains utilizing double refocused hyperbolic tangent (DRHT) and 8-segment B1-insensitive rotation (BIR-8). This was done using both numerical simulations and phantom studies to evaluate their sensitivities to gradient imperfections such as eddy currents. DRHT, BIR-8, and FT-VSS prepared CBV mapping was further compared for velocity-encoding gradients along 3 orthogonal directions in healthy subjects at 3T. Results: The phantom studies exhibited more consistent immunity to gradient imperfections for the utilized FT-VSS pulse trains. Compared to DRHT and BIR-8, FT-VSS delivered more robust CBV results across the 3 VS encoding directions with significantly reduced artifacts along the superior-inferior direction and improved temporal signal-to-noise ratio (SNR) values. Average CBV values obtained from FT-VSS based sequences were 5.3 mL/100 g for gray matter and 2.3 mL/100 g for white matter, comparable to literature expectations. Conclusion: Absolute CBV quantification utilizing advanced FT-VSS pulse trains had several advantages over the existing approaches using flow-dephasing VSS modules. A greater immunity to gradient imperfections and the concurrent tissue background suppression of FT-VSS pulse trains enabled more robust CBV measurements and higher SNR than the conventional VSS pulse trains.

KW - arterial spin labeling

KW - cerebral blood volume

KW - eddy current

KW - Fourier-transform–based velocity-selective saturation

KW - velocity-selective pulse train

UR - http://www.scopus.com/inward/record.url?scp=85061278268&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061278268&partnerID=8YFLogxK

U2 - 10.1002/mrm.27668

DO - 10.1002/mrm.27668

M3 - Article

C2 - 30737847

AN - SCOPUS:85061278268

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

ER -