Cerebral blood flow measured by stable xenon enhanced computerized tomography compared to H215O positron emission tomography

Edwin Nemoto, Yonas Howard, Ronda Pindzola, Hiroto Kuwabara, Donald Sashin

Research output: Contribution to journalArticle

Abstract

Background and aims: Both the vasodilatory effect of stable xenon and the limited blood brain barrier permeability of H215O on cerebral blood flow (CBF) measured by CT and PET, respectively, have been extensively studied with a general consensus that PET CBF is the gold standard for comparison (1). Methods: We measured CBF by stable xenon-CT (Xe/CT) (28% xenon in 40% oxygen for 4.5 min) and within 24 hrs, by dynamic PET with H215O in 12 symptomatic stroke patients which allowed comparison of the CBF values using both Methods: in the major cerebral vascular territories, white matter, and basal ganglia in 4 axial slices in each patient. Results: The linear regression relationship between PET CBF and Xe/CT CBF was described by the equation: PET CBF = 0.608 (Xe/CT CBF) + 3.204, R=0.693, P

Original languageEnglish (US)
JournalJournal of Cerebral Blood Flow and Metabolism
Volume27
Issue numberSUPPL. 1
StatePublished - Nov 13 2007

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Cerebrovascular Circulation
Xenon
Positron-Emission Tomography
Tomography
Basal Ganglia
Blood-Brain Barrier
Blood Vessels
Linear Models
Permeability
Stroke
Oxygen

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

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Cerebral blood flow measured by stable xenon enhanced computerized tomography compared to H215O positron emission tomography. / Nemoto, Edwin; Howard, Yonas; Pindzola, Ronda; Kuwabara, Hiroto; Sashin, Donald.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 27, No. SUPPL. 1, 13.11.2007.

Research output: Contribution to journalArticle

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