Cerebral blood flow and oxygen consumption in rat, measured with microspheres or xenon

A. Gjedde, S. M. DeLaMonte, J. J. Caronna

Research output: Contribution to journalArticle

Abstract

The cerebral blood flow and, in some rats, the cerebral rate of oxygen consumption were measured in three groups of male rats. Fractionation of radioisotope-labeled microspheres was used to measure regional cerebral blood flow in four parts of the rat brain. The arterial and cerebral venous concentrations of radioactive xenon during desaturation were used to measure the blood flow and oxygen consumption of cortex when venous blood was collected from the superior sagittal sinus, or of whole brain when the transverse sinus was sampled. The regional cerebral blood flow measured with microspheres had a large standard error reflecting the technical difficulty of this method. The cerebral blood flow measured with xenon was higher when venous blood was sampled from the superior sagittal sinus than when sampled from the transverse sinus, but cerebral oxygen consumption rates were similar. The difference reflects the greater trauma involved in the superior sagittal approach and possible extracerebral contamination present in the transverse sinus approach.

Original languageEnglish (US)
Pages (from-to)273-281
Number of pages9
JournalActa Physiologica Scandinavica
Volume100
Issue number3
StatePublished - 1977
Externally publishedYes

Fingerprint

Cerebrovascular Circulation
Xenon
Transverse Sinuses
Microspheres
Oxygen Consumption
Superior Sagittal Sinus
Regional Blood Flow
Brain
Radioisotopes
Wounds and Injuries

ASJC Scopus subject areas

  • Physiology

Cite this

Cerebral blood flow and oxygen consumption in rat, measured with microspheres or xenon. / Gjedde, A.; DeLaMonte, S. M.; Caronna, J. J.

In: Acta Physiologica Scandinavica, Vol. 100, No. 3, 1977, p. 273-281.

Research output: Contribution to journalArticle

Gjedde, A, DeLaMonte, SM & Caronna, JJ 1977, 'Cerebral blood flow and oxygen consumption in rat, measured with microspheres or xenon', Acta Physiologica Scandinavica, vol. 100, no. 3, pp. 273-281.
Gjedde, A. ; DeLaMonte, S. M. ; Caronna, J. J. / Cerebral blood flow and oxygen consumption in rat, measured with microspheres or xenon. In: Acta Physiologica Scandinavica. 1977 ; Vol. 100, No. 3. pp. 273-281.
@article{715851cb61814d20be4bfb598780698d,
title = "Cerebral blood flow and oxygen consumption in rat, measured with microspheres or xenon",
abstract = "The cerebral blood flow and, in some rats, the cerebral rate of oxygen consumption were measured in three groups of male rats. Fractionation of radioisotope-labeled microspheres was used to measure regional cerebral blood flow in four parts of the rat brain. The arterial and cerebral venous concentrations of radioactive xenon during desaturation were used to measure the blood flow and oxygen consumption of cortex when venous blood was collected from the superior sagittal sinus, or of whole brain when the transverse sinus was sampled. The regional cerebral blood flow measured with microspheres had a large standard error reflecting the technical difficulty of this method. The cerebral blood flow measured with xenon was higher when venous blood was sampled from the superior sagittal sinus than when sampled from the transverse sinus, but cerebral oxygen consumption rates were similar. The difference reflects the greater trauma involved in the superior sagittal approach and possible extracerebral contamination present in the transverse sinus approach.",
author = "A. Gjedde and DeLaMonte, {S. M.} and Caronna, {J. J.}",
year = "1977",
language = "English (US)",
volume = "100",
pages = "273--281",
journal = "Acta Physiologica Scandinavica",
issn = "0370-839X",
publisher = "Wiley-Blackwell",
number = "3",

}

TY - JOUR

T1 - Cerebral blood flow and oxygen consumption in rat, measured with microspheres or xenon

AU - Gjedde, A.

AU - DeLaMonte, S. M.

AU - Caronna, J. J.

PY - 1977

Y1 - 1977

N2 - The cerebral blood flow and, in some rats, the cerebral rate of oxygen consumption were measured in three groups of male rats. Fractionation of radioisotope-labeled microspheres was used to measure regional cerebral blood flow in four parts of the rat brain. The arterial and cerebral venous concentrations of radioactive xenon during desaturation were used to measure the blood flow and oxygen consumption of cortex when venous blood was collected from the superior sagittal sinus, or of whole brain when the transverse sinus was sampled. The regional cerebral blood flow measured with microspheres had a large standard error reflecting the technical difficulty of this method. The cerebral blood flow measured with xenon was higher when venous blood was sampled from the superior sagittal sinus than when sampled from the transverse sinus, but cerebral oxygen consumption rates were similar. The difference reflects the greater trauma involved in the superior sagittal approach and possible extracerebral contamination present in the transverse sinus approach.

AB - The cerebral blood flow and, in some rats, the cerebral rate of oxygen consumption were measured in three groups of male rats. Fractionation of radioisotope-labeled microspheres was used to measure regional cerebral blood flow in four parts of the rat brain. The arterial and cerebral venous concentrations of radioactive xenon during desaturation were used to measure the blood flow and oxygen consumption of cortex when venous blood was collected from the superior sagittal sinus, or of whole brain when the transverse sinus was sampled. The regional cerebral blood flow measured with microspheres had a large standard error reflecting the technical difficulty of this method. The cerebral blood flow measured with xenon was higher when venous blood was sampled from the superior sagittal sinus than when sampled from the transverse sinus, but cerebral oxygen consumption rates were similar. The difference reflects the greater trauma involved in the superior sagittal approach and possible extracerebral contamination present in the transverse sinus approach.

UR - http://www.scopus.com/inward/record.url?scp=0017744474&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017744474&partnerID=8YFLogxK

M3 - Article

C2 - 21517

AN - SCOPUS:0017744474

VL - 100

SP - 273

EP - 281

JO - Acta Physiologica Scandinavica

JF - Acta Physiologica Scandinavica

SN - 0370-839X

IS - 3

ER -