Cerebral arterial bolus arrival time is prolonged in multiple sclerosis and associated with disability

David Paling, Esben Thade Petersen, Daniel J. Tozer, Daniel R. Altmann, Claudia A.M. Wheeler-Kingshott, Raju Kapoor, David H. Miller, Xavier Golay

Research output: Contribution to journalArticlepeer-review

Abstract

Alterations in the overall cerebral hemodynamics have been reported in multiple sclerosis (MS); however, their cause and significance is unknown. While potential venous causes have been examined, arterial causes have not. In this study, a multiple delay time arterial spin labeling magnetic resonance imaging sequence at 3T was used to quantify the arterial hemodynamic parameter bolus arrival time (BAT) and cerebral blood flow (CBF) in normal-appearing white matter (NAWM) and deep gray matter in 33 controls and 35 patients with relapsing-remitting MS. Bolus arrival time was prolonged in MS in NAWM (1.0±0.2 versus 0.9±0.2 seconds, P=0.031) and deep gray matter (0.90±0.18 versus 0.80±0.14 seconds, P=0.001) and CBF was increased in NAWM (14±4 versus 10±2 mL/100 g/min, P=0.001). Prolonged BAT in NAWM (P=0.042) and deep gray matter (P=0.01) were associated with higher expanded disability status score. This study demonstrates alteration in cerebral arterial hemodynamics in MS. One possible cause may be widespread inflammation. Bolus arrival time was longer in patients with greater disability independent of atrophy and T2 lesion load, suggesting alterations in cerebral arterial hemodynamics may be a marker of clinically relevant pathology.

Original languageEnglish (US)
Pages (from-to)34-42
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Volume34
Issue number1
DOIs
StatePublished - Jan 2014

Keywords

  • hemodynamics
  • inflammation
  • magnetic resonance imaging
  • multiple sclerosis
  • perfusion imaging
  • relapsingremitting

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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