Cerebellar disruptions and neurodevelopmental disabilities

Thangamadhan Bosemani, Andrea Poretti

Research output: Contribution to journalReview articlepeer-review

Abstract

The vulnerability of the cerebellum during prenatal life to disruptive events such as hemorrhage and infection leads to a wide variety of morphological abnormalities. This review discusses various prenatal cerebellar disruptions including cerebellar agenesis, unilateral cerebellar hypoplasia, cerebellar cleft, global cerebellar hypoplasia, and vanishing cerebellum in Chiari type II malformation. For each entity, we discuss the definition, potential pathomechanism, clinical findings including neurocognitive and behavioral problems, neuroimaging features, and management. Accurate recognition of cerebellar disruptions and their differentiation from malformations is important in terms of diagnosis, prognosis, and genetic counselling.

Original languageEnglish (US)
Pages (from-to)339-348
Number of pages10
JournalSeminars in Fetal and Neonatal Medicine
Volume21
Issue number5
DOIs
StatePublished - Oct 1 2016

Keywords

  • Cerebellum
  • Disability
  • Disruption
  • Magnetic resonance imaging
  • Neurodevelopment
  • Prenatal

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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