Cerebellar cleft: Confirmation of the neuroimaging pattern

A. Poretti, T. A.G.M. Huisman, F. M. Cowan, E. Del Giudice, P. Y. Jeannet, D. Prayer, M. A. Rutherford, A. J. Du Plessis, C. Limperopoulos, E. Boltshauser

Research output: Contribution to journalArticlepeer-review

Abstract

We recently described the neuroimaging and clinical findings in 6 children with cerebellar clefts and proposed that they result from disruptive changes following prenatal cerebellar hemorrhage. We now report an additional series of 9 patients analyzing the clinical and neuroimaging findings. The clefts were located in the left cerebellar hemisphere in 5 cases, in the right in 3, and bilaterally in one child who had bilateral cerebellar hemorrhages as a preterm infant at 30 weeks gestation. In one patient born at 24 weeks of gestation a unilateral cerebellar hemorrhage has been found at the age of 4 months. Other findings included disordered alignment of the folia and fissures, an irregular gray/white matter junction, and abnormal arborization of the white matter in all cases. Supratentorial abnormalities were found in 4 cases. All but 2 patients were born at term. We confirm the distinct neuroimaging pattern of cerebellar clefts. Considering the documented fetal cerebellar hemorrhage in our first series, we postulate that cerebellar clefts usually represent residual disruptive changes after a prenatal cerebellar hemorrhage. Exceptionally, as now documented in 2 patients, cerebellar clefts can be found after neonatal cerebellar hemorrhages in preterm infants. The short-term outcome in these children was variable.

Original languageEnglish (US)
Pages (from-to)228-233
Number of pages6
JournalNeuropediatrics
Volume40
Issue number5
DOIs
StatePublished - Dec 1 2009

Keywords

  • cerebellar cleft
  • cerebellar disruption
  • cerebellar hemorrhage

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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