Anomalie cérébelleuse chez des enfants et adultes jeunes présentant une sclérose tubéreuse complexe: aspects en IRM cérébrale et imagerie de diffusion

Translated title of the contribution: Cerebellar abnormality in children and young adults with tuberous sclerosis complex: MR and diffusion weighted imaging findings

G. Ertan, S. Arulrajah, A. Tekes, L. Jordan, T. A.G.M. Huisman

Research output: Contribution to journalArticle

Abstract

Objectives: The goal of our study was to: determine the incidence of cerebellar lesions in a cohort of children and young adults with TSC, and analyze the magnetic resonance imaging (MRI) findings of cerebellar TSC lesions including their contrast behavior and diffusion characteristics. Material and Methods: MRI studies of 27 TSC patients (mean age, 10.6 years) were evaluated for: cortical/subcortical tubers, white matter lesions, subependymal nodules, and giant cell astrocytomas. Patients with cerebellar involvement were further analyzed for the imaging and diffusion characteristics. ADC measurements of the cerebellar tubers were performed and compared with the contralateral normal appearing cerebellum. The clinical charts were revisited for symptoms suggesting cerebellar involvement. Results: Cerebellar tubers were seen in 8/27 patients, cerebellar atrophy in 1/27 patients. Cerebellar tubers showed a pyramidal/wedge appearance with a broad base reaching the cortex. The majority of the cerebellar tubers (11/12, 92%) showed a " zebra-like" contrast enhancement. All cerebellar tubers had increased ADC values (mean ADC 1472×10-6 mm2/s). None of the patients had " typical" cerebellar symptoms. Conclusion: Thirty-three percent of TSC patients had cerebellar lesions, most of them being cerebellar tubers. Cerebellar tubers differ from supratentorial tubers both concerning shape and contrast behavior. The exact etiology of contrast enhancement remains unclear. Future studies have to determine the impact of cerebellar lesions on neurocognitive development.

Original languageFrench
Pages (from-to)231-238
Number of pages8
JournalJournal of Neuroradiology
Volume37
Issue number4
DOIs
StatePublished - Oct 1 2010

    Fingerprint

Keywords

  • Cerebellum
  • Children
  • Diffusion weighted imaging
  • Tuberous sclerosis complex

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology

Cite this