Cephalometric features in isolated growth hormone deficiency

Luiz Alves Oliveira-Neto, Maria De Fátima B. Melo, Alexandre A. Franco, Alaíde H.A. Oliveira, Anita H.O. Souza, Euĝnia H.O. Valença, Isabela M.P.A. Britto, Roberto Salvatori, Manuel H. Aguiar-Oliveira

Research output: Contribution to journalArticle


Objective: To analyze cephalometric features in adults with isolated growth hormone (GH) deficiency (IGHD). Materials and Methods: Nine adult IGHD individuals (7 males and 2 females; mean age, 37.8 ± 13.8 years) underwent a cross-sectional cephalometric study, including 9 linear and 5 angular measurements. Posterior facial height/anterior facial height and lower-anterior facial height/anterior facial height ratios were calculated. To pool cephalometric measurements in both genders, results were normalized by standard deviation scores (SDS), using the population means from an atlas of the normal Brazilian population. Results: All linear measurements were reduced in IGHD subjects. Total maxillary length was the most reduced parameter (26.5 ± 1.7), followed by a cluster of six measurements: posterior cranial base length (24.9 ± 1.1), total mandibular length (24.4 ± 0.7), total posterior facial height (24.4 ± 1.1), total anterior facial height (24.3 ± 0.9), mandibular corpus length (24.2 ± 0.8), and anterior cranial base length (24.1 ± 1.7). Less affected measurements were lower-anterior facial height (22.7 ± 0.7) and mandibular ramus height (22.5 ± 1.5). SDS angular measurements were in the normal range, except for increased gonial angle (+2.5 ± 1.1). Posterior facial height/anterior facial height and lower-anterior facial height/anterior facial height ratios were not different from those of the reference group. Conclusions: Congenital, untreated IGHD causes reduction of all linear measurements of craniofacial growth, particularly total maxillary length. Angular measurements and facial height ratios are less affected, suggesting that lGHD causes proportional blunting of craniofacial growth.

Original languageEnglish (US)
Pages (from-to)578-583
Number of pages6
JournalAngle Orthodontist
Issue number4
StatePublished - Jul 1 2011


  • Craniofacial growth
  • Growth hormone
  • Isolated GH deficiency

ASJC Scopus subject areas

  • Orthodontics

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    Oliveira-Neto, L. A., Melo, M. D. F. B., Franco, A. A., Oliveira, A. H. A., Souza, A. H. O., Valença, E. H. O., Britto, I. M. P. A., Salvatori, R., & Aguiar-Oliveira, M. H. (2011). Cephalometric features in isolated growth hormone deficiency. Angle Orthodontist, 81(4), 578-583. https://doi.org/10.2319/102210-618.1