TY - JOUR
T1 - Centrum semiovale white matter CT changes associated with normal ageing, Alzheimer's disease and late life depression with and without reversible dementia
AU - Pearlson, Godfrey D.
AU - Rabins, Peter V.
AU - Burns, Alistair
N1 - Funding Information:
Dr Rabins was supported in part by the Oscar and Lillian Stempler Foundation, the Eleanor and T. Rowe Price Foundation, and Grant Nos. MHOO5O5 and MH18316 from the National Institute of Mental Health.
Funding Information:
Dr Pearlson was supported in part by Grant Nos. MH40391 and MH43775 from the National Institute of Mental Health, the Alzheimer's Disease and Related Disorders Association, and from the Johns Hopkins Outpatient Clinical Research Center (NIH RR00722, NIH Division of Resource Research).
PY - 1991
Y1 - 1991
N2 - A standardized, reliable means of assessing CT attenuation numbers in the centrum semiovale and surrounding grey matter was developed. This was applied to cranial CT scans of 60 normal controls (36 aged > 60 years), 25 elderly patients with major depression (14 of whom had the dementia syndrome of depression), and 10 patients with Alzheimer's disease (AD). Subjects received neuropsychological evaluation. Centrum semiovale (CSO) CT attenuation numbers decreased with increasing age for both white and grey matter. White matter attenuation values best discriminated elderly controls from the three patient groups. Both white and grey matter CSO attenuation values correlated with performance on a number of cognitive tasks.
AB - A standardized, reliable means of assessing CT attenuation numbers in the centrum semiovale and surrounding grey matter was developed. This was applied to cranial CT scans of 60 normal controls (36 aged > 60 years), 25 elderly patients with major depression (14 of whom had the dementia syndrome of depression), and 10 patients with Alzheimer's disease (AD). Subjects received neuropsychological evaluation. Centrum semiovale (CSO) CT attenuation numbers decreased with increasing age for both white and grey matter. White matter attenuation values best discriminated elderly controls from the three patient groups. Both white and grey matter CSO attenuation values correlated with performance on a number of cognitive tasks.
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U2 - 10.1017/S0033291700020420
DO - 10.1017/S0033291700020420
M3 - Article
C2 - 1876637
AN - SCOPUS:0025760139
SN - 0033-2917
VL - 21
SP - 321
EP - 328
JO - Psychological medicine
JF - Psychological medicine
IS - 2
ER -