Centroacinar cells: At the center of pancreas regeneration

Rebecca L. Beer, Michael J. Parsons, Meritxell Rovira

Research output: Contribution to journalReview articlepeer-review

Abstract

The process of regeneration serves to heal injury by replacing missing cells. Understanding regeneration can help us replace cell populations lost during disease, such as the insulin-producing β cells lost in diabetic patients. Centroacinar cells (CACs) are a specialized ductal pancreatic cell type that act as progenitors to replace β cells in the zebrafish. However, whether CACs contribute to β-cell regeneration in adult mammals remains controversial. Here we review the current understanding of the role of CACs as endocrine progenitors during regeneration in zebrafish and mammals.

Original languageEnglish (US)
Pages (from-to)8-15
Number of pages8
JournalDevelopmental biology
Volume413
Issue number1
DOIs
StatePublished - May 1 2016

Keywords

  • Centroacinar cell
  • Pancreas
  • Progenitor
  • Regeneration
  • Zebrafish
  • β cell

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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