Abstract
The process of regeneration serves to heal injury by replacing missing cells. Understanding regeneration can help us replace cell populations lost during disease, such as the insulin-producing β cells lost in diabetic patients. Centroacinar cells (CACs) are a specialized ductal pancreatic cell type that act as progenitors to replace β cells in the zebrafish. However, whether CACs contribute to β-cell regeneration in adult mammals remains controversial. Here we review the current understanding of the role of CACs as endocrine progenitors during regeneration in zebrafish and mammals.
Original language | English (US) |
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Pages (from-to) | 8-15 |
Number of pages | 8 |
Journal | Developmental biology |
Volume | 413 |
Issue number | 1 |
DOIs | |
State | Published - May 1 2016 |
Keywords
- Centroacinar cell
- Pancreas
- Progenitor
- Regeneration
- Zebrafish
- β cell
ASJC Scopus subject areas
- Molecular Biology
- Developmental Biology
- Cell Biology