Centrizonal arteries and microvessels in nonalcoholic steatohepatitis

Ryan M. Gill, Patricia Belt, Laura Wilson, Nathan M. Bass, Linda D. Ferrell

Research output: Contribution to journalArticle

Abstract

Correct classification of nonalcoholic steatohepatitis (NASH) liver biopsies is of critical importance and relies on correct orientation to microscopic liver architecture. Centrizonal arteries can cause central zones to be mistaken for portal tracts, especially in the setting of centrizonal ductular reaction, and result in either missed diagnosis or inaccurate staging of NASH. A total of 100 randomly selected biopsies from NASH Clinical Research Network participants (February 2005 to August 2006, fibrosis stage >1a) were evaluated for arteries and CD34-positive microvessels in the centrizonal region. Prevalence of both centrizonal arteries and CD34-positive microvessels was graded as 0 (none in central zones), 1 (1 to 2 central zones with vessels), 2 (

Original languageEnglish (US)
Pages (from-to)1400-1404
Number of pages5
JournalAmerican Journal of Surgical Pathology
Volume35
Issue number9
DOIs
StatePublished - Sep 2011
Externally publishedYes

Fingerprint

Microvessels
Arteries
Biopsy
Liver
Fibrosis
Research
Non-alcoholic Fatty Liver Disease

Keywords

  • angiogenesis
  • central zones
  • hepatic vasculature
  • nonalcoholic fatty liver disease
  • steatohepatitis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Centrizonal arteries and microvessels in nonalcoholic steatohepatitis. / Gill, Ryan M.; Belt, Patricia; Wilson, Laura; Bass, Nathan M.; Ferrell, Linda D.

In: American Journal of Surgical Pathology, Vol. 35, No. 9, 09.2011, p. 1400-1404.

Research output: Contribution to journalArticle

Gill, Ryan M. ; Belt, Patricia ; Wilson, Laura ; Bass, Nathan M. ; Ferrell, Linda D. / Centrizonal arteries and microvessels in nonalcoholic steatohepatitis. In: American Journal of Surgical Pathology. 2011 ; Vol. 35, No. 9. pp. 1400-1404.
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