Centriole duplication: A lesson in self-control

Andrew J. Holland, Weijie Lan, Don W. Cleveland

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


In interphase and mitosis, centrosomes play a major role in the spatial organization of the microtubule network. Alterations in centrosome number and structure are associated with genomic instability and occur in many cancers. Centrosome duplication is controlled by centriole replication. In most dividing animal cells, centrioles duplicate only once per cell cycle at a site adjacent to existing centrioles. The conserved protein kinase Polo-like kinase 4 (Plk4) has a key role in controlling centriole biogenesis. Overexpression of Plk4 drives centrosome amplification and is associated with tumorigenesis in flies. By contrast, haploinsufficiency of Plk4 promotes cytokinesis failure, leading to an increased incidence of tumors in mice. Recent studies have shown that Plk4 is a low abundance protein whose stability is linked to the activity of the enzyme. We discuss how this autoregulatory feedback loop acts to limit the damaging effects caused by too much or too little Plk4.

Original languageEnglish (US)
Pages (from-to)2803-2808
Number of pages6
JournalCell Cycle
Issue number14
StatePublished - Jul 15 2010
Externally publishedYes


  • Aneuploidy
  • Centriole
  • Centrosome
  • Phosphodegron
  • Plk4
  • Pololike kinase 4
  • SAK
  • SCF
  • β-TrCP

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology


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