Abstract
Central pontine myelinolysis (CPM) is a rare, acute, and uniformly fatal demyelinative process that involves the pons almost exclusively. Three cases diagnosed at autopsy illustrate the characteristic clinical course and pathologic features of CPM. A unique extrapontine location of a similar process is noted in the medulla of a 6-year-old girl. The term "medullary myelinolysis" is a descriptive designation for demyelination that occurs predominantly in this area. The clinical and pathologic features of CPM are reviewed in detail, together with a brief review of theories of metabolic, nutritional, vascular, and endogenous and exogenous toxic factors that act either singly or in concert in the cause and pathogenesis of CPM.
Original language | English (US) |
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Pages (from-to) | 246-252 |
Number of pages | 7 |
Journal | Archives of Pathology and Laboratory Medicine |
Volume | 100 |
Issue number | 5 |
State | Published - May 1976 |
Externally published | Yes |
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology