Central or peripheral systolic or pulse pressure: Which best relates to target organs and future mortality?

Kang Ling Wang, Hao Min Cheng, Shao Yuan Chuang, Harold A. Spurgeon, Chih Tai Ting, Edward Lakatta, Frank C P Yin, Pesus Chou, Chen Huan Chen

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To examine the relationship between brachial and central carotid pressures and target organ indices at baseline and their association with future mortality. METHODS: We examined, cross-sectionally and longitudinally, the relations of baseline systolic and pulse pressures in central (calibrated tonometric carotid pulse) and peripheral (brachial, mercury sphygmomanometer) arteries to baseline left ventricular mass, carotid intima-media thickness, estimated glomerular filtration rate, and 10-year all-cause and cardiovascular mortality in 1272 participants (47% women aged 30-79 years) from a community of homogeneous Chinese. RESULTS: Left ventricular mass was more strongly related to central and peripheral systolic pressures than pulse pressures. Intima-media thickness and glomerular filtration rate were more strongly related to central pressures than peripheral pressures. A total of 130 participants died, 37 from cardiovascular causes. In univariate analysis, all four blood pressure variables significantly predicted all-cause and cardiovascular mortality. Each blood pressure variable was entered into the multivariate models, both individually and jointly with another blood pressure variable. After adjustment for age, sex, heart rate, BMI, current smoking, glucose, ratio of total cholesterol to high-density lipoprotein cholesterol, carotid-femoral pulse wave velocity, left ventricular mass, intima-media thickness, and glomerular filtration rate, only central systolic pressure consistently and independently predicted cardiovascular mortality (hazards ratio, 1.30 per 10 mmHg). No significant sex interactions were observed in all analyses. CONCLUSION: Systolic and pulse pressures relate differently to different target organs. Central systolic pressure is more valuable than other blood pressure variables in predicting cardiovascular mortality.

Original languageEnglish (US)
Pages (from-to)461-467
Number of pages7
JournalJournal of Hypertension
Volume27
Issue number3
DOIs
StatePublished - Mar 2009
Externally publishedYes

Fingerprint

Blood Pressure
Mortality
Glomerular Filtration Rate
Pressure
Arm
Sphygmomanometers
Mass Media
Carotid Intima-Media Thickness
Pulse Wave Analysis
Thigh
Mercury
HDL Cholesterol
Pulse
Arteries
Heart Rate
Smoking
Cholesterol
Glucose

Keywords

  • Central blood pressure
  • Glomerular filtration rate
  • Mortality
  • Pulse pressure

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Central or peripheral systolic or pulse pressure : Which best relates to target organs and future mortality? / Wang, Kang Ling; Cheng, Hao Min; Chuang, Shao Yuan; Spurgeon, Harold A.; Ting, Chih Tai; Lakatta, Edward; Yin, Frank C P; Chou, Pesus; Chen, Chen Huan.

In: Journal of Hypertension, Vol. 27, No. 3, 03.2009, p. 461-467.

Research output: Contribution to journalArticle

Wang, KL, Cheng, HM, Chuang, SY, Spurgeon, HA, Ting, CT, Lakatta, E, Yin, FCP, Chou, P & Chen, CH 2009, 'Central or peripheral systolic or pulse pressure: Which best relates to target organs and future mortality?', Journal of Hypertension, vol. 27, no. 3, pp. 461-467. https://doi.org/10.1097/HJH.0b013e3283220ea4
Wang, Kang Ling ; Cheng, Hao Min ; Chuang, Shao Yuan ; Spurgeon, Harold A. ; Ting, Chih Tai ; Lakatta, Edward ; Yin, Frank C P ; Chou, Pesus ; Chen, Chen Huan. / Central or peripheral systolic or pulse pressure : Which best relates to target organs and future mortality?. In: Journal of Hypertension. 2009 ; Vol. 27, No. 3. pp. 461-467.
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T2 - Which best relates to target organs and future mortality?

AU - Wang, Kang Ling

AU - Cheng, Hao Min

AU - Chuang, Shao Yuan

AU - Spurgeon, Harold A.

AU - Ting, Chih Tai

AU - Lakatta, Edward

AU - Yin, Frank C P

AU - Chou, Pesus

AU - Chen, Chen Huan

PY - 2009/3

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N2 - OBJECTIVE: To examine the relationship between brachial and central carotid pressures and target organ indices at baseline and their association with future mortality. METHODS: We examined, cross-sectionally and longitudinally, the relations of baseline systolic and pulse pressures in central (calibrated tonometric carotid pulse) and peripheral (brachial, mercury sphygmomanometer) arteries to baseline left ventricular mass, carotid intima-media thickness, estimated glomerular filtration rate, and 10-year all-cause and cardiovascular mortality in 1272 participants (47% women aged 30-79 years) from a community of homogeneous Chinese. RESULTS: Left ventricular mass was more strongly related to central and peripheral systolic pressures than pulse pressures. Intima-media thickness and glomerular filtration rate were more strongly related to central pressures than peripheral pressures. A total of 130 participants died, 37 from cardiovascular causes. In univariate analysis, all four blood pressure variables significantly predicted all-cause and cardiovascular mortality. Each blood pressure variable was entered into the multivariate models, both individually and jointly with another blood pressure variable. After adjustment for age, sex, heart rate, BMI, current smoking, glucose, ratio of total cholesterol to high-density lipoprotein cholesterol, carotid-femoral pulse wave velocity, left ventricular mass, intima-media thickness, and glomerular filtration rate, only central systolic pressure consistently and independently predicted cardiovascular mortality (hazards ratio, 1.30 per 10 mmHg). No significant sex interactions were observed in all analyses. CONCLUSION: Systolic and pulse pressures relate differently to different target organs. Central systolic pressure is more valuable than other blood pressure variables in predicting cardiovascular mortality.

AB - OBJECTIVE: To examine the relationship between brachial and central carotid pressures and target organ indices at baseline and their association with future mortality. METHODS: We examined, cross-sectionally and longitudinally, the relations of baseline systolic and pulse pressures in central (calibrated tonometric carotid pulse) and peripheral (brachial, mercury sphygmomanometer) arteries to baseline left ventricular mass, carotid intima-media thickness, estimated glomerular filtration rate, and 10-year all-cause and cardiovascular mortality in 1272 participants (47% women aged 30-79 years) from a community of homogeneous Chinese. RESULTS: Left ventricular mass was more strongly related to central and peripheral systolic pressures than pulse pressures. Intima-media thickness and glomerular filtration rate were more strongly related to central pressures than peripheral pressures. A total of 130 participants died, 37 from cardiovascular causes. In univariate analysis, all four blood pressure variables significantly predicted all-cause and cardiovascular mortality. Each blood pressure variable was entered into the multivariate models, both individually and jointly with another blood pressure variable. After adjustment for age, sex, heart rate, BMI, current smoking, glucose, ratio of total cholesterol to high-density lipoprotein cholesterol, carotid-femoral pulse wave velocity, left ventricular mass, intima-media thickness, and glomerular filtration rate, only central systolic pressure consistently and independently predicted cardiovascular mortality (hazards ratio, 1.30 per 10 mmHg). No significant sex interactions were observed in all analyses. CONCLUSION: Systolic and pulse pressures relate differently to different target organs. Central systolic pressure is more valuable than other blood pressure variables in predicting cardiovascular mortality.

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KW - Glomerular filtration rate

KW - Mortality

KW - Pulse pressure

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