Central nervous system cancers

Louis Burt Nabors, Mario Ammirati, Philip J. Bierman, Henry Brem, Nicholas Butowski, Marc C. Chamberlain, Lisa M. DeAngelis, Robert A. Fenstermaker, Allan Friedman, Mark R. Gilbert, Deneen Hesser, Matthias Holdhoff, Larry Junck, Ronald Lawson, Jay S. Loeffler, Moshe H. Maor, Paul L. Moots, Tara Morrison, Maciej M. Mrugala, Herbert B. NewtonJana Portnow, Jeffrey J. Raizer, Lawrence Recht, Dennis C. Shrieve, Allen K. Sills, David Tran, Nam Tran, Frank D. Vrionis, Patrick Y. Wen, Maria Ho

Research output: Contribution to journalReview article

Abstract

Primary and metastatic tumors of the central nervous system are a heterogeneous group of neoplasms with varied outcomes and management strategies. Recently, improved survival observed in 2 randomized clinical trials established combined chemotherapy and radiation as the new standard for treating patients with pure or mixed anaplastic oligodendroglioma harboring the 1p/19q codeletion. For metastatic disease, increasing evidence supports the efficacy of stereotactic radiosurgery in treating patients with multiple metastatic lesions but low overall tumor volume. These guidelines provide recommendations on the diagnosis and management of this group of diseases based on clinical evidence and panel consensus. This version includes expert advice on the management of low-grade infiltrative astrocytomas, oligodendrogliomas, anaplastic gliomas, glioblastomas, medulloblastomas, supratentorial primitive neuroectodermal tumors, and brain metastases. The full online version, available at NCCN. org, contains recommendations on additional subtypes.

Original languageEnglish (US)
Pages (from-to)1114-1151
Number of pages38
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume11
Issue number9
DOIs
StatePublished - Sep 1 2013

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Burt Nabors, L., Ammirati, M., Bierman, P. J., Brem, H., Butowski, N., Chamberlain, M. C., DeAngelis, L. M., Fenstermaker, R. A., Friedman, A., Gilbert, M. R., Hesser, D., Holdhoff, M., Junck, L., Lawson, R., Loeffler, J. S., Maor, M. H., Moots, P. L., Morrison, T., Mrugala, M. M., ... Ho, M. (2013). Central nervous system cancers. JNCCN Journal of the National Comprehensive Cancer Network, 11(9), 1114-1151. https://doi.org/10.6004/jnccn.2013.0132