TY - JOUR
T1 - Central nervous system and peripheral hormone responses to a meal in children
AU - Roth, Christian L.
AU - Melhorn, Susan J.
AU - Elfers, Clinton T.
AU - Scholz, Kelley
AU - De Leon, Mary Rosalynn B.
AU - Rowland, Maya
AU - Kearns, Sue
AU - Aylward, Elizabeth
AU - Grabowski, Thomas J.
AU - Saelens, Brian E.
AU - Schur, Ellen A.
N1 - Funding Information:
This work was supported by National Institutes of Health Grants R01DK098466 and R01DK104936 (to C.L.R.), R01DK089036 (E.A.S.), P30DK035816 (to the University of Washington Nutrition and Obesity Research Center), and by the University of Washington Institute of Translational Health Sciences (supported by National Institutes of Health National Center for Advancing Translational Sciences Grants UL1TR000423, KL2TR000421, and TL1TR000422).
Publisher Copyright:
Copyright © 2019 Endocrine Society.
PY - 2019
Y1 - 2019
N2 - Context: Behavioral studies suggest that responses to food consumption are altered in children with obesity (OB). Objective: To test central nervous system and peripheral hormone response by functional MRI and satiety-regulating hormone levels before and after a meal. Design and Setting: Cross-sectional study comparing children with OB and children of healthy weight (HW) recruited from across the Puget Sound region of Washington. Participants: Children (9 to 11 years old; OB, n = 54; HW, n = 22), matched for age and sex. Intervention and Outcome Measures: Neural activation to images of high- and low-calorie food and objectswas evaluated across a set ofapriori appetite-processing regions that included the ventral and dorsal striatum, amygdala, substantia nigra/ventral tegmental area, insula, and medial orbitofrontal cortex. Premeal and postmeal hormones (insulin, peptide YY, glucagon-like peptide-1, active ghrelin) were measured. Results: In response to a meal, average brain activation by high-calorie food cues vs objects in a priori regions was reduced after meals in children of HW (Z = -3.5, P < 0.0001), but not in children with OB (z = 0.28, P = 0.78) despite appropriate meal responses by gut hormones. Although premeal average brain activation by high-calorie food cues was lower in children with OB vs children of HW, postmeal activation was higher in children with OB (Z = -2.1, P = 0.04 and Z = 2.3, P = 0.02, respectively). An attenuated central response to a meal was associated with greater degree of insulin resistance. Conclusions: Our data suggest that children with OB exhibit an attenuated central, as opposed to gut hormone, response to a meal, which may predispose them to overconsumption of food or difficulty with weight loss.
AB - Context: Behavioral studies suggest that responses to food consumption are altered in children with obesity (OB). Objective: To test central nervous system and peripheral hormone response by functional MRI and satiety-regulating hormone levels before and after a meal. Design and Setting: Cross-sectional study comparing children with OB and children of healthy weight (HW) recruited from across the Puget Sound region of Washington. Participants: Children (9 to 11 years old; OB, n = 54; HW, n = 22), matched for age and sex. Intervention and Outcome Measures: Neural activation to images of high- and low-calorie food and objectswas evaluated across a set ofapriori appetite-processing regions that included the ventral and dorsal striatum, amygdala, substantia nigra/ventral tegmental area, insula, and medial orbitofrontal cortex. Premeal and postmeal hormones (insulin, peptide YY, glucagon-like peptide-1, active ghrelin) were measured. Results: In response to a meal, average brain activation by high-calorie food cues vs objects in a priori regions was reduced after meals in children of HW (Z = -3.5, P < 0.0001), but not in children with OB (z = 0.28, P = 0.78) despite appropriate meal responses by gut hormones. Although premeal average brain activation by high-calorie food cues was lower in children with OB vs children of HW, postmeal activation was higher in children with OB (Z = -2.1, P = 0.04 and Z = 2.3, P = 0.02, respectively). An attenuated central response to a meal was associated with greater degree of insulin resistance. Conclusions: Our data suggest that children with OB exhibit an attenuated central, as opposed to gut hormone, response to a meal, which may predispose them to overconsumption of food or difficulty with weight loss.
UR - http://www.scopus.com/inward/record.url?scp=85063942050&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063942050&partnerID=8YFLogxK
U2 - 10.1210/jc.2018-01525
DO - 10.1210/jc.2018-01525
M3 - Article
C2 - 30418574
AN - SCOPUS:85063942050
VL - 104
SP - 1471
EP - 1483
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
SN - 0021-972X
IS - 5
ER -