Central and peripheral vagal transport of cholecystokinin binding sites occurs in afferent fibers

Timothy H. Moran, Ralph Norgren, Robert J. Crosby, Paul R. McHugh

Research output: Contribution to journalArticle

Abstract

The effects of various vagal lesions on cholecystokinin (CCK) binding sites in the nucleus tractus solitarii (NTS) and area postrema (AP) and the peripheral transport of CCK binding sites in the cervical vagus were examined in rats by in vitro autoradiography with [125I]CCK-8. Unilateral supraganglionic, but not subdiaphragmatic, vagotomy significantly reduced CCK binding in the ipsilateral NTS. Specific unilateral afferent, but not efferent, vagal rootlet transections also significantly reduced NTS CCK binding ipsilateral to the transections. None of the vagal lesions altered CCK binding in the AP. Infraganglionic but not supraganglionic vagotomy eliminated the peripheral transport of vagal CCK binding sites. Together these results demonstrate that CCK receptors in the NTS are located on vagal afferent terminals, that CCK receptors in the AP are likely postsynaptic to a vagal afferent input and that the peripheral and central transport of vagal CCK binding sites occurs in afferent fibers.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalBrain research
Volume526
Issue number1
DOIs
StatePublished - Aug 27 1990

Keywords

  • Area postrema
  • Cholecystokinin
  • Nodose ganglion
  • Nucleus tractus solitarii
  • Receptor
  • Vagus nerve

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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