Central actions of adipocyte hormones

Research output: Contribution to journalReview articlepeer-review

127 Scopus citations

Abstract

Adipose tissue secretes a variety of proteins with important roles in metabolism, reproduction, immunity and cardiovascular function. The endocrine function of adipose tissue, especially that of leptin, is linked to energy storage and thus might provide insights into obesity and other diseases associated with energy imbalance. This review highlights the current understanding of the actions of leptin in the brain, with particular emphasis on transport across the blood-brain barrier, signal transduction, neuropeptide targets and roles during fasting and obesity. Moreover, data pertaining to the potential central effects of adiponectin, cytokines and resistin on energy homeostasis, glucose and lipid metabolism are discussed.

Original languageEnglish (US)
Pages (from-to)307-313
Number of pages7
JournalTrends in Endocrinology and Metabolism
Volume16
Issue number7
DOIs
StatePublished - Sep 2005
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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