Cellular UV damage responses - Functions of tumor suppressor p53

Leena Latonen, Marikki Laiho

Research output: Contribution to journalArticle

Abstract

DNA damage, provoked by ultraviolet (UV) radiation, evokes a cellular damage response composed of activation of stress signaling and DNA checkpoint functions. These are translated to responses of replicative arrest, damage repair, and apoptosis aimed at cellular recovery from the damage. p53 tumor suppressor is a central stress response protein, activated by multiple endogenous and environmental insults, including UV radiation. The significance of p53 in the DNA damage responses has frequently been reviewed in the context of ionizing radiation or other double strand break (DSB)-inducing agents. Despite partly similar patterns, the molecular events following UV radiation are, however, distinct from the responses induced by DSBs and are profoundly coupled with transcriptional stress. These are illustrated, e.g., by the UV damage-specific translocations of Mdm2, promyelocytic leukemia protein, and nucleophosmin and their interactions with p53. In this review, we discuss UV damage-provoked cellular responses and the functions of p53 in damage recovery and cell death.

Original languageEnglish (US)
Pages (from-to)71-89
Number of pages19
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1755
Issue number2
DOIs
StatePublished - Jul 25 2005
Externally publishedYes

Fingerprint

Radiation
DNA Damage
Neoplasms
Heat-Shock Proteins
Ionizing Radiation
Cell Death
Apoptosis
DNA
Promyelocytic Leukemia Protein
1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione
nucleophosmin

Keywords

  • Apoptosis
  • Cell cycle arrest
  • DNA damage
  • Nucleotide excision repair
  • p53 tumor suppressor
  • UV radiation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Biophysics

Cite this

Cellular UV damage responses - Functions of tumor suppressor p53. / Latonen, Leena; Laiho, Marikki.

In: Biochimica et Biophysica Acta - Reviews on Cancer, Vol. 1755, No. 2, 25.07.2005, p. 71-89.

Research output: Contribution to journalArticle

@article{564e04912cbc4af99f6127e9b829ef7d,
title = "Cellular UV damage responses - Functions of tumor suppressor p53",
abstract = "DNA damage, provoked by ultraviolet (UV) radiation, evokes a cellular damage response composed of activation of stress signaling and DNA checkpoint functions. These are translated to responses of replicative arrest, damage repair, and apoptosis aimed at cellular recovery from the damage. p53 tumor suppressor is a central stress response protein, activated by multiple endogenous and environmental insults, including UV radiation. The significance of p53 in the DNA damage responses has frequently been reviewed in the context of ionizing radiation or other double strand break (DSB)-inducing agents. Despite partly similar patterns, the molecular events following UV radiation are, however, distinct from the responses induced by DSBs and are profoundly coupled with transcriptional stress. These are illustrated, e.g., by the UV damage-specific translocations of Mdm2, promyelocytic leukemia protein, and nucleophosmin and their interactions with p53. In this review, we discuss UV damage-provoked cellular responses and the functions of p53 in damage recovery and cell death.",
keywords = "Apoptosis, Cell cycle arrest, DNA damage, Nucleotide excision repair, p53 tumor suppressor, UV radiation",
author = "Leena Latonen and Marikki Laiho",
year = "2005",
month = "7",
day = "25",
doi = "10.1016/j.bbcan.2005.04.003",
language = "English (US)",
volume = "1755",
pages = "71--89",
journal = "Biochimica et Biophysica Acta - Reviews on Cancer",
issn = "0304-419X",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Cellular UV damage responses - Functions of tumor suppressor p53

AU - Latonen, Leena

AU - Laiho, Marikki

PY - 2005/7/25

Y1 - 2005/7/25

N2 - DNA damage, provoked by ultraviolet (UV) radiation, evokes a cellular damage response composed of activation of stress signaling and DNA checkpoint functions. These are translated to responses of replicative arrest, damage repair, and apoptosis aimed at cellular recovery from the damage. p53 tumor suppressor is a central stress response protein, activated by multiple endogenous and environmental insults, including UV radiation. The significance of p53 in the DNA damage responses has frequently been reviewed in the context of ionizing radiation or other double strand break (DSB)-inducing agents. Despite partly similar patterns, the molecular events following UV radiation are, however, distinct from the responses induced by DSBs and are profoundly coupled with transcriptional stress. These are illustrated, e.g., by the UV damage-specific translocations of Mdm2, promyelocytic leukemia protein, and nucleophosmin and their interactions with p53. In this review, we discuss UV damage-provoked cellular responses and the functions of p53 in damage recovery and cell death.

AB - DNA damage, provoked by ultraviolet (UV) radiation, evokes a cellular damage response composed of activation of stress signaling and DNA checkpoint functions. These are translated to responses of replicative arrest, damage repair, and apoptosis aimed at cellular recovery from the damage. p53 tumor suppressor is a central stress response protein, activated by multiple endogenous and environmental insults, including UV radiation. The significance of p53 in the DNA damage responses has frequently been reviewed in the context of ionizing radiation or other double strand break (DSB)-inducing agents. Despite partly similar patterns, the molecular events following UV radiation are, however, distinct from the responses induced by DSBs and are profoundly coupled with transcriptional stress. These are illustrated, e.g., by the UV damage-specific translocations of Mdm2, promyelocytic leukemia protein, and nucleophosmin and their interactions with p53. In this review, we discuss UV damage-provoked cellular responses and the functions of p53 in damage recovery and cell death.

KW - Apoptosis

KW - Cell cycle arrest

KW - DNA damage

KW - Nucleotide excision repair

KW - p53 tumor suppressor

KW - UV radiation

UR - http://www.scopus.com/inward/record.url?scp=22144460207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=22144460207&partnerID=8YFLogxK

U2 - 10.1016/j.bbcan.2005.04.003

DO - 10.1016/j.bbcan.2005.04.003

M3 - Article

C2 - 15921859

AN - SCOPUS:22144460207

VL - 1755

SP - 71

EP - 89

JO - Biochimica et Biophysica Acta - Reviews on Cancer

JF - Biochimica et Biophysica Acta - Reviews on Cancer

SN - 0304-419X

IS - 2

ER -