Cellular UV damage responses - Functions of tumor suppressor p53

Leena Latonen, Marikki Laiho

Research output: Contribution to journalReview article

Abstract

DNA damage, provoked by ultraviolet (UV) radiation, evokes a cellular damage response composed of activation of stress signaling and DNA checkpoint functions. These are translated to responses of replicative arrest, damage repair, and apoptosis aimed at cellular recovery from the damage. p53 tumor suppressor is a central stress response protein, activated by multiple endogenous and environmental insults, including UV radiation. The significance of p53 in the DNA damage responses has frequently been reviewed in the context of ionizing radiation or other double strand break (DSB)-inducing agents. Despite partly similar patterns, the molecular events following UV radiation are, however, distinct from the responses induced by DSBs and are profoundly coupled with transcriptional stress. These are illustrated, e.g., by the UV damage-specific translocations of Mdm2, promyelocytic leukemia protein, and nucleophosmin and their interactions with p53. In this review, we discuss UV damage-provoked cellular responses and the functions of p53 in damage recovery and cell death.

Original languageEnglish (US)
Pages (from-to)71-89
Number of pages19
JournalBiochimica et Biophysica Acta - Reviews on Cancer
Volume1755
Issue number2
DOIs
StatePublished - Jul 25 2005

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Keywords

  • Apoptosis
  • Cell cycle arrest
  • DNA damage
  • Nucleotide excision repair
  • UV radiation
  • p53 tumor suppressor

ASJC Scopus subject areas

  • Oncology
  • Genetics
  • Cancer Research

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