Cellular uptake of cadmium and zinc

Alice J. Corrigan, P. C. Huang

Research output: Contribution to journalArticlepeer-review

Abstract

CHO mutants, resistant to over 100-fold of a normally toxic level of extracellular cadmium have been used to examine the mutually antagonistic effect of Cd and Zn on their uptake. Cadmium uptake in these mutants is only 7-10% that of the parental cells. Zinc uptake in these mutants is equal to or greater than that in the wild-type cells. Results of kinetic studies on uptake indicated that the two metals interact by competitive inhibition. The Km and Ki values for Cd and/or Zn were different in some of the mutants and indicate multiple carriers may be involved in the transport of these metals. The reduction in Cd uptake and concomitant increase in Zn uptake contribute to the increased Cd resistance in these mutants.

Original languageEnglish (US)
Pages (from-to)197-216
Number of pages20
JournalBiological Trace Element Research
Volume3
Issue number3
DOIs
StatePublished - Sep 1 1981

Keywords

  • CHO cells, Cd and Zn uptake in
  • Cadmium, cellular uptake of
  • antagonism, of Cd and Zn in cellular uptake
  • metallothionein, in cellular uptake of Cd and Zn
  • transport, of Cd and Zn in cellular uptake
  • zinc, cellular uptake of

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry

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