Cellular Specificity of NF-κB Function in the Nervous System

Erica C. Dresselhaus, Mollie K Meffert

Research output: Contribution to journalReview article

Abstract

Nuclear Factor Kappa B (NF-κB) is a ubiquitously expressed transcription factor with key functions in a wide array of biological systems. While the role of NF-κB in processes, such as host immunity and oncogenesis has been more clearly defined, an understanding of the basic functions of NF-κB in the nervous system has lagged behind. The vast cell-type heterogeneity within the central nervous system (CNS) and the interplay between cell-type specific roles of NF-κB contributes to the complexity of understanding NF-κB functions in the brain. In this review, we will focus on the emerging understanding of cell-autonomous regulation of NF-κB signaling as well as the non-cell-autonomous functional impacts of NF-κB activation in the mammalian nervous system. We will focus on recent work which is unlocking the pleiotropic roles of NF-κB in neurons and glial cells (including astrocytes and microglia). Normal physiology as well as disorders of the CNS in which NF-κB signaling has been implicated will be discussed with reference to the lens of cell-type specific responses.

Original languageEnglish (US)
Number of pages1
JournalFrontiers in immunology
Volume10
DOIs
StatePublished - Jan 1 2019

Fingerprint

NF-kappa B
Nervous System
Central Nervous System Diseases
Microglia
Neuroglia
Astrocytes
Lenses
Immunity
Carcinogenesis
Transcription Factors
Central Nervous System
Neurons
Brain

Keywords

  • central nervous system (CNS)
  • gene expression
  • glia
  • Neurons
  • NF-κB
  • Plasticity
  • synapse
  • transcription

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Cellular Specificity of NF-κB Function in the Nervous System. / Dresselhaus, Erica C.; Meffert, Mollie K.

In: Frontiers in immunology, Vol. 10, 01.01.2019.

Research output: Contribution to journalReview article

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N2 - Nuclear Factor Kappa B (NF-κB) is a ubiquitously expressed transcription factor with key functions in a wide array of biological systems. While the role of NF-κB in processes, such as host immunity and oncogenesis has been more clearly defined, an understanding of the basic functions of NF-κB in the nervous system has lagged behind. The vast cell-type heterogeneity within the central nervous system (CNS) and the interplay between cell-type specific roles of NF-κB contributes to the complexity of understanding NF-κB functions in the brain. In this review, we will focus on the emerging understanding of cell-autonomous regulation of NF-κB signaling as well as the non-cell-autonomous functional impacts of NF-κB activation in the mammalian nervous system. We will focus on recent work which is unlocking the pleiotropic roles of NF-κB in neurons and glial cells (including astrocytes and microglia). Normal physiology as well as disorders of the CNS in which NF-κB signaling has been implicated will be discussed with reference to the lens of cell-type specific responses.

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