TY - JOUR
T1 - Cellular responses to electrical stimulation
T2 - A study using a model of the ventricular cardiac action potential
AU - Rudy, Y.
AU - Luo, C. H.
AU - Beyar, R.
AU - Marban, E.
AU - Bassingthwaighte, J.
PY - 1993
Y1 - 1993
N2 - A mathematical model of the membrane action potential of a ventricular cardiac cell is used to examine the cellular responses to premature stimulation. Results demonstrate the importance of the slow recovery of I(Na) in determining the response of the cell. Simulated responses to periodic stimulation include monotonic Wenckebach patterns and alternans in APD at normal [K](o). At low [K](o), nonmonotonic Wenckebach periodicities, aperiodic patterns, and enhanced supernormal excitability that results in unstable responses ('chaotic activity') are observed. These observations are consistent with recent experimental results, and the simulations provide insights into the underlying mechanisms at the level of membrane ionic channel kinetics.
AB - A mathematical model of the membrane action potential of a ventricular cardiac cell is used to examine the cellular responses to premature stimulation. Results demonstrate the importance of the slow recovery of I(Na) in determining the response of the cell. Simulated responses to periodic stimulation include monotonic Wenckebach patterns and alternans in APD at normal [K](o). At low [K](o), nonmonotonic Wenckebach periodicities, aperiodic patterns, and enhanced supernormal excitability that results in unstable responses ('chaotic activity') are observed. These observations are consistent with recent experimental results, and the simulations provide insights into the underlying mechanisms at the level of membrane ionic channel kinetics.
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M3 - Article
C2 - 8184783
AN - SCOPUS:0027743572
SN - 0065-2598
VL - 346
SP - 79
EP - 90
JO - Advances in Experimental Medicine and Biology
JF - Advances in Experimental Medicine and Biology
ER -