Cellular proliferation in pilocytic and diffuse astrocytomas

C. Giannini, B. W. Scheithauer, P. C. Burger, M. R. Christensen, P. C. Wollan, T. J. Sebo, P. A. Forsyth, C. J. Hayostek

Research output: Contribution to journalArticle

Abstract

Using quantitative image analysis, we evaluated the MIB-1 labeling index (LI) in a large population of pilocytic (n = 131) and diffuse astrocytomas (n = 140), explored its significance as a prognostic predictor of survival, and compared it to other commonly accepted predictors, including grade and its histologic determinants, atypia, mitoses, endothelial proliferation, and necrosis. Diffuse astrocytomas were graded according to the St Anne-Mayo scheme and included 45 grade 2, 50 grade 3, and 45 grade 4 astrocytomas. In pilocytic astrocytomas, mean, median, and range of MIB-1 LIs were 1.1, 0.9, and 0-3.9%, respectively. In diffuse astrocytomas, these values were 2.3, 2, and 0-7.6% in grade 2; 6, 4.4, and 0.1-25.7% in grade 3; 9.1, 6, and 0.3-36% in grade 4. There was a significant difference in the distribution of MIB-1 LIs between pilocytic and diffuse grade 2 astrocytomas (p <0.001), between grade 2 and grade 3 (p <0.001), and between tumors of grade 3 and 4 (p = 0.014). Among pilocytic astrocytomas there was no association between survival and MIB-1 LI or any histologic parameter. In diffuse astrocytomas, MIB-1 LI was significantly correlated with grade as well as with mitotic activity (1 mitosis and, compared to the latter, had a significantly longer survival (p = 0.013), one not significantly different from patients with grade 2 astrocytomas. These findings suggest that the cutoff point between grade 2 and 3 in the St. Anne- Mayo scheme may not be optimal and may need to be revised.

Original languageEnglish (US)
Pages (from-to)46-53
Number of pages8
JournalJournal of Neuropathology and Experimental Neurology
Volume58
Issue number1
StatePublished - 1999

Fingerprint

Astrocytoma
Cell Proliferation
Mitosis
Survival
Necrosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Giannini, C., Scheithauer, B. W., Burger, P. C., Christensen, M. R., Wollan, P. C., Sebo, T. J., ... Hayostek, C. J. (1999). Cellular proliferation in pilocytic and diffuse astrocytomas. Journal of Neuropathology and Experimental Neurology, 58(1), 46-53.

Cellular proliferation in pilocytic and diffuse astrocytomas. / Giannini, C.; Scheithauer, B. W.; Burger, P. C.; Christensen, M. R.; Wollan, P. C.; Sebo, T. J.; Forsyth, P. A.; Hayostek, C. J.

In: Journal of Neuropathology and Experimental Neurology, Vol. 58, No. 1, 1999, p. 46-53.

Research output: Contribution to journalArticle

Giannini, C, Scheithauer, BW, Burger, PC, Christensen, MR, Wollan, PC, Sebo, TJ, Forsyth, PA & Hayostek, CJ 1999, 'Cellular proliferation in pilocytic and diffuse astrocytomas', Journal of Neuropathology and Experimental Neurology, vol. 58, no. 1, pp. 46-53.
Giannini C, Scheithauer BW, Burger PC, Christensen MR, Wollan PC, Sebo TJ et al. Cellular proliferation in pilocytic and diffuse astrocytomas. Journal of Neuropathology and Experimental Neurology. 1999;58(1):46-53.
Giannini, C. ; Scheithauer, B. W. ; Burger, P. C. ; Christensen, M. R. ; Wollan, P. C. ; Sebo, T. J. ; Forsyth, P. A. ; Hayostek, C. J. / Cellular proliferation in pilocytic and diffuse astrocytomas. In: Journal of Neuropathology and Experimental Neurology. 1999 ; Vol. 58, No. 1. pp. 46-53.
@article{690933b1bc8c45229e06ea590de26a66,
title = "Cellular proliferation in pilocytic and diffuse astrocytomas",
abstract = "Using quantitative image analysis, we evaluated the MIB-1 labeling index (LI) in a large population of pilocytic (n = 131) and diffuse astrocytomas (n = 140), explored its significance as a prognostic predictor of survival, and compared it to other commonly accepted predictors, including grade and its histologic determinants, atypia, mitoses, endothelial proliferation, and necrosis. Diffuse astrocytomas were graded according to the St Anne-Mayo scheme and included 45 grade 2, 50 grade 3, and 45 grade 4 astrocytomas. In pilocytic astrocytomas, mean, median, and range of MIB-1 LIs were 1.1, 0.9, and 0-3.9{\%}, respectively. In diffuse astrocytomas, these values were 2.3, 2, and 0-7.6{\%} in grade 2; 6, 4.4, and 0.1-25.7{\%} in grade 3; 9.1, 6, and 0.3-36{\%} in grade 4. There was a significant difference in the distribution of MIB-1 LIs between pilocytic and diffuse grade 2 astrocytomas (p <0.001), between grade 2 and grade 3 (p <0.001), and between tumors of grade 3 and 4 (p = 0.014). Among pilocytic astrocytomas there was no association between survival and MIB-1 LI or any histologic parameter. In diffuse astrocytomas, MIB-1 LI was significantly correlated with grade as well as with mitotic activity (1 mitosis and, compared to the latter, had a significantly longer survival (p = 0.013), one not significantly different from patients with grade 2 astrocytomas. These findings suggest that the cutoff point between grade 2 and 3 in the St. Anne- Mayo scheme may not be optimal and may need to be revised.",
author = "C. Giannini and Scheithauer, {B. W.} and Burger, {P. C.} and Christensen, {M. R.} and Wollan, {P. C.} and Sebo, {T. J.} and Forsyth, {P. A.} and Hayostek, {C. J.}",
year = "1999",
language = "English (US)",
volume = "58",
pages = "46--53",
journal = "American Journal of Psychotherapy",
issn = "0002-9564",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Cellular proliferation in pilocytic and diffuse astrocytomas

AU - Giannini, C.

AU - Scheithauer, B. W.

AU - Burger, P. C.

AU - Christensen, M. R.

AU - Wollan, P. C.

AU - Sebo, T. J.

AU - Forsyth, P. A.

AU - Hayostek, C. J.

PY - 1999

Y1 - 1999

N2 - Using quantitative image analysis, we evaluated the MIB-1 labeling index (LI) in a large population of pilocytic (n = 131) and diffuse astrocytomas (n = 140), explored its significance as a prognostic predictor of survival, and compared it to other commonly accepted predictors, including grade and its histologic determinants, atypia, mitoses, endothelial proliferation, and necrosis. Diffuse astrocytomas were graded according to the St Anne-Mayo scheme and included 45 grade 2, 50 grade 3, and 45 grade 4 astrocytomas. In pilocytic astrocytomas, mean, median, and range of MIB-1 LIs were 1.1, 0.9, and 0-3.9%, respectively. In diffuse astrocytomas, these values were 2.3, 2, and 0-7.6% in grade 2; 6, 4.4, and 0.1-25.7% in grade 3; 9.1, 6, and 0.3-36% in grade 4. There was a significant difference in the distribution of MIB-1 LIs between pilocytic and diffuse grade 2 astrocytomas (p <0.001), between grade 2 and grade 3 (p <0.001), and between tumors of grade 3 and 4 (p = 0.014). Among pilocytic astrocytomas there was no association between survival and MIB-1 LI or any histologic parameter. In diffuse astrocytomas, MIB-1 LI was significantly correlated with grade as well as with mitotic activity (1 mitosis and, compared to the latter, had a significantly longer survival (p = 0.013), one not significantly different from patients with grade 2 astrocytomas. These findings suggest that the cutoff point between grade 2 and 3 in the St. Anne- Mayo scheme may not be optimal and may need to be revised.

AB - Using quantitative image analysis, we evaluated the MIB-1 labeling index (LI) in a large population of pilocytic (n = 131) and diffuse astrocytomas (n = 140), explored its significance as a prognostic predictor of survival, and compared it to other commonly accepted predictors, including grade and its histologic determinants, atypia, mitoses, endothelial proliferation, and necrosis. Diffuse astrocytomas were graded according to the St Anne-Mayo scheme and included 45 grade 2, 50 grade 3, and 45 grade 4 astrocytomas. In pilocytic astrocytomas, mean, median, and range of MIB-1 LIs were 1.1, 0.9, and 0-3.9%, respectively. In diffuse astrocytomas, these values were 2.3, 2, and 0-7.6% in grade 2; 6, 4.4, and 0.1-25.7% in grade 3; 9.1, 6, and 0.3-36% in grade 4. There was a significant difference in the distribution of MIB-1 LIs between pilocytic and diffuse grade 2 astrocytomas (p <0.001), between grade 2 and grade 3 (p <0.001), and between tumors of grade 3 and 4 (p = 0.014). Among pilocytic astrocytomas there was no association between survival and MIB-1 LI or any histologic parameter. In diffuse astrocytomas, MIB-1 LI was significantly correlated with grade as well as with mitotic activity (1 mitosis and, compared to the latter, had a significantly longer survival (p = 0.013), one not significantly different from patients with grade 2 astrocytomas. These findings suggest that the cutoff point between grade 2 and 3 in the St. Anne- Mayo scheme may not be optimal and may need to be revised.

UR - http://www.scopus.com/inward/record.url?scp=0032944497&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032944497&partnerID=8YFLogxK

M3 - Article

VL - 58

SP - 46

EP - 53

JO - American Journal of Psychotherapy

JF - American Journal of Psychotherapy

SN - 0002-9564

IS - 1

ER -