Cellular pathways promoting pulmonary vascular remodeling by hypoxia

Research output: Contribution to journalReview articlepeer-review

Abstract

Exposure to hypoxia increases pulmonary vascular resistance, leading to elevated pulmonary arterial pressure and, potentially, right heart failure. Vascular remodeling is an important contributor to the increased pulmonary vascular resistance. Hyperproliferation of smooth muscle, endothelial cells, and fibro-blasts, and deposition of extracellular matrix lead to increased wall thickness, extension of muscle into normally non-muscular arterioles, and vascular stiff-ening. This review highlights intrinsic and extrinsic modulators contributing to the remodeling process.

Original languageEnglish (US)
Pages (from-to)222-233
Number of pages12
JournalPhysiology
Volume35
Issue number4
DOIs
StatePublished - Jul 2020

Keywords

  • Heart failure
  • Hypoxia
  • Remodeling

ASJC Scopus subject areas

  • Physiology

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