Cellular niches for endogenous neural stem cells in the adult brain

J. Dedrick Jordan, Dengke K. Ma, Guo Li Ming, Hongjun Song

Research output: Contribution to journalArticle

Abstract

Neural stem cells are present throughout life and continuously give rise to new neurons and glia cells in the mammalian central nervous system. Accumulating evidence suggests essential roles of micro-environments, or niches, in supporting active neurogenesis from endogenous neural stem cells within restricted regions of the adult brain. These neurogenic niches also regulate different steps of adult neurogenesis in response to physiological and pathological stimulations. Recent studies have identified several cellular niche components, including endothelial cells, astroglia, ependymal cells, immature progeny of NSCs and mature neurons. In this review, we discuss identified niche signals from these cellular components in regulating different steps of adult neurogenesis. We also highlight some of the potential therapeutic targets to be manipulated within neurogenic niche for repair of the adult central nervous system.

Original languageEnglish (US)
Pages (from-to)336-341
Number of pages6
JournalCNS and Neurological Disorders - Drug Targets
Volume6
Issue number5
DOIs
StatePublished - Oct 2007

Keywords

  • Central nervous system
  • GABA transporters
  • Hippocampus
  • Pigment epithelial differentiation factor
  • Subventricular zone

ASJC Scopus subject areas

  • Neuroscience(all)
  • Pharmacology

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