Cellular mechanisms of acute hypoxic pulmonary vasoconstriction

J. T. Sylvester, James Sham, Larissa Shimoda, Q. Liu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Although acute hypoxic pulmonary vasoconstriction (HPV; see Table 1) has been studied intensively for over 50 years, its mechanisms remain unclear. Understanding these mechanisms is important because HPV plays significant roles in both normal and diseased lungs. In normal lungs, HPV maximizes systemic arterial oxygen tension by diverting pulmonary blood flow from poorly ventilated hypoxic lung regions to well ventilated normoxic lung regions. In diseased lungs, where hypoxia is diffuse, HPV occurs throughout the pulmonary vasculature, resulting in pulmonary hypertension, right ventricular failure, and increased morbidity and mortality.

Original languageEnglish (US)
Title of host publicationRespiratory-Circulatory Interactions in Health and Disease
PublisherCRC Press
Pages315-360
Number of pages46
ISBN (Electronic)9780824741747
ISBN (Print)9780824704742
StatePublished - Jan 1 2001

Fingerprint

Vasoconstriction
Lung
Lung Diseases
Pulmonary Hypertension
Arterial Pressure
Oxygen
Morbidity
Mortality

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sylvester, J. T., Sham, J., Shimoda, L., & Liu, Q. (2001). Cellular mechanisms of acute hypoxic pulmonary vasoconstriction. In Respiratory-Circulatory Interactions in Health and Disease (pp. 315-360). CRC Press.

Cellular mechanisms of acute hypoxic pulmonary vasoconstriction. / Sylvester, J. T.; Sham, James; Shimoda, Larissa; Liu, Q.

Respiratory-Circulatory Interactions in Health and Disease. CRC Press, 2001. p. 315-360.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sylvester, JT, Sham, J, Shimoda, L & Liu, Q 2001, Cellular mechanisms of acute hypoxic pulmonary vasoconstriction. in Respiratory-Circulatory Interactions in Health and Disease. CRC Press, pp. 315-360.
Sylvester JT, Sham J, Shimoda L, Liu Q. Cellular mechanisms of acute hypoxic pulmonary vasoconstriction. In Respiratory-Circulatory Interactions in Health and Disease. CRC Press. 2001. p. 315-360
Sylvester, J. T. ; Sham, James ; Shimoda, Larissa ; Liu, Q. / Cellular mechanisms of acute hypoxic pulmonary vasoconstriction. Respiratory-Circulatory Interactions in Health and Disease. CRC Press, 2001. pp. 315-360
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