Cellular immunity to heterotopic corneal allografts in the rat

P. A. Treseler, C. B. Treseler, G. N. Foulks, F. Sanfilippo

Research output: Contribution to journalArticlepeer-review

Abstract

Although the immune nature of corneal allograft rejection has been recognized for over thirty years, the specific mechanisms involved in such reactions remain obscure. We investigated the cellular immune responses of PVG (RT1(c)) rats that were grafted with fully allogeneic ACI (RT1(a)) skin, ACI cornea, or PVG cornea to the chest wall or given sham grafts. Cell-mediated lymphocytotoxicity (CML) was tested at 10 days posttransplant by placing recipient spleen cells in culture with irradiated ACI stimulator cells, and six days later measuring specific lysis of 51Cr-labeled target lymphoblasts at several effector-to-target ratios. Effector cells from animals receiving allogeneic skin or cornea grafts lysed targets from the donor (ACI) strain at levels significantly (P

Original languageEnglish (US)
Pages (from-to)196-201
Number of pages6
JournalTransplantation
Volume39
Issue number2
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Immunology
  • Transplantation

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