Cellular immune responses to HPV-18, -31, and -53 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles

Ligia A. Pinto, Raphael Viscidi, Clayton D. Harro, Troy J. Kemp, Alfonso J. García-Piñeres, Matthew Trivett, Franklin Demuth, Douglas R. Lowy, John T. Schiller, Jay A. Berzofsky, Allan Hildesheim

Research output: Contribution to journalArticle

Abstract

Human papillomavirus-like particles (HPV VLP) are candidate vaccines that have shown to be efficacious in reducing infection and inducing robust antiviral immunity. Neutralizing antibodies generated by vaccination are largely type-specific, but little is known about the type-specificity of cellular immune responses to VLP vaccination. To determine whether vaccination with HPV-16 L1VLP induces cellular immunity to heterologous HPV types (HPV-18, HPV-31, and HPV-53), we examined proliferative and cytokine responses in vaccine (n = 11) and placebo (n = 5) recipients. Increased proliferative and cytokine responses to heterologous types were observed postvaccination in some individuals. The proportion of women responding to heterologous types postvaccination (36%-55%) was lower than that observed in response to HPV-16 (73%). Response to HPV-16 VLP predicted response to other types. The strongest correlations in response were observed between HPV-16 and HPV-31, consistent with their phylogenetic relatedness. In summary, PBMC from HPV-16 VLP vaccine recipients can respond to L1VLP from heterologous HPV types, suggesting the presence of conserved T cell epitopes.

Original languageEnglish (US)
Pages (from-to)451-462
Number of pages12
JournalVirology
Volume353
Issue number2
DOIs
StatePublished - Sep 30 2006

Keywords

  • Cytokines
  • Infectious diseases
  • T cells
  • Vaccination

ASJC Scopus subject areas

  • Virology

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  • Cite this

    Pinto, L. A., Viscidi, R., Harro, C. D., Kemp, T. J., García-Piñeres, A. J., Trivett, M., Demuth, F., Lowy, D. R., Schiller, J. T., Berzofsky, J. A., & Hildesheim, A. (2006). Cellular immune responses to HPV-18, -31, and -53 in healthy volunteers immunized with recombinant HPV-16 L1 virus-like particles. Virology, 353(2), 451-462. https://doi.org/10.1016/j.virol.2006.06.021