Cellular immune response parameters that influence IgE sensitization

Pamela A. Frischmeyer-Guerrerio, John T. Schroeder

Research output: Contribution to journalArticlepeer-review

Abstract

In vitro basophil responses have longed been used in mechanistic studies to help assess the human allergic diathesis, particularly during therapeutic intervention. Recent evidence points to the use of dendritic cells (DCs) in also being valuable in evaluating therapies aimed at lessening disease through immunomodulation. This review article therefore takes a look at some of the recent advances in old and new assays employing both basophils and DCs, with the added perception that the responses mediated by two cell types are insightful towards understanding immune cell mechanisms underlying allergic disease.

Original languageEnglish (US)
Pages (from-to)21-29
Number of pages9
JournalJournal of Immunological Methods
Volume383
Issue number1-2
DOIs
StatePublished - Sep 28 2012

Keywords

  • Basophil
  • Cytokine
  • Dendritic cell
  • Human
  • Mediators
  • Methods

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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