TY - JOUR
T1 - Cellular foundations of mammary tubulogenesis
AU - Huebner, Robert J.
AU - Ewald, Andrew J.
N1 - Funding Information:
The authors thank Neil Neumann and Eliah Shamir for critical comments on the manuscript. R.J.H. was supported by an NIH/NIGMS training grant ( 2T32GM007445 ). A.J.E. and R.J.H. were both supported in part by a Research Scholar Grant, RSG-12-141-01 – CSM from the American Cancer Society . A.J.E. was supported in part by the Breast Cancer Research Foundation and by NIH/NCI U01 CA155758.
PY - 2014/7
Y1 - 2014/7
N2 - The mammary gland is composed of a highly branched network of epithelial tubes, embedded within a complex stroma. The mammary epithelium originates during embryonic development from an epidermal placode. However, the majority of ductal elongation and bifurcation occurs postnatally, in response to steroid hormone and growth factor receptor signaling. The process of pubertal branching morphogenesis involves both elongation of the primary ducts across the length of the fat pad and a wave of secondary branching that elaborates the ductal network. Recent studies have revealed that mammary epithelial morphogenesis is accomplished by transitions between simple and stratified organization. During active morphogenesis, the epithelium is stratified, highly proliferative, has few intercellular junctions, and exhibits incomplete apico-basal polarity. In this review, we discuss recent advances in our understanding of the relationship between epithelial architecture, epithelial polarity, and ductal elongation.
AB - The mammary gland is composed of a highly branched network of epithelial tubes, embedded within a complex stroma. The mammary epithelium originates during embryonic development from an epidermal placode. However, the majority of ductal elongation and bifurcation occurs postnatally, in response to steroid hormone and growth factor receptor signaling. The process of pubertal branching morphogenesis involves both elongation of the primary ducts across the length of the fat pad and a wave of secondary branching that elaborates the ductal network. Recent studies have revealed that mammary epithelial morphogenesis is accomplished by transitions between simple and stratified organization. During active morphogenesis, the epithelium is stratified, highly proliferative, has few intercellular junctions, and exhibits incomplete apico-basal polarity. In this review, we discuss recent advances in our understanding of the relationship between epithelial architecture, epithelial polarity, and ductal elongation.
KW - Apico-basal polarity
KW - Branching morphogenesis
KW - Breast cancer
KW - Collective cell migration
KW - Mammary gland
KW - Tubulogenesis
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U2 - 10.1016/j.semcdb.2014.04.019
DO - 10.1016/j.semcdb.2014.04.019
M3 - Review article
C2 - 24747369
AN - SCOPUS:84901997778
SN - 1084-9521
VL - 31
SP - 124
EP - 131
JO - Seminars in Cell and Developmental Biology
JF - Seminars in Cell and Developmental Biology
ER -