Cellular FLICE-like inhibitory protein long form (c-FLIPL) overexpression is related to cervical cancer progression

Carmen Gloria Ili, Priscilla Brebi, Oscar Tapia, Alejandra Sandoval, Jaime Lopez, Patricia Garcia, Pamela Leal, David Sidransky, Rafael Guerrero-Preston, Juan Carlos Roa

Research output: Contribution to journalArticlepeer-review

Abstract

Cervical cancer is a leading cause of cancer deaths in women worldwide and infection by high-risk human papillomavirus types is a precursor event. The cellular FLICE-like inhibitory protein (c-FLIP) has been found to be overexpressed in several types of cancers and could be associated with cervical cancer progression because of its ability to inhibit the apoptotic process. To detect c-FLIP expression in cervical cancer, an immunohistochemical staining was performed, using tissue microarrays, on a series of 536 archival biopsy samples, including normal cervical tissues, low-grade and high-grade squamous intraepithelial lesions, and squamous cervical carcinomas. The epithelium in the normal cervix and low-grade squamous intraepithelial lesions mainly stained negatively for c-FLIP, whereas high-grade intraepithelial lesions and cancer samples showed an elevated expression of c-FLIP. A direct association was observed between the increasing grade of the lesion and the intensity of c-FLIP staining, in which the frequency of intense c-FLIP expression increased from 12.5% in the normal tissue to 82.1% in the cervical cancer tissue. An increased expression of c-FLIP may be an important factor in the progression of cervical cancer. This finding could aid in identifying patients with preneoplastic lesions at greater risk of developing cervical cancer. c-FLIP expression in cervical tissue may be a potential cervical cancer progression marker.

Original languageEnglish (US)
Pages (from-to)316-322
Number of pages7
JournalInternational Journal of Gynecological Pathology
Volume32
Issue number3
DOIs
StatePublished - May 2013

Keywords

  • Cervical cancer
  • Immunohistochemestry
  • c-FLIP

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

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