The reaginic hypersensitivity reactions in atopic diseases are mediated by IgE antibody. IgE antibody response is highly dependent on antigen-specific T cells, and collaboration between T and B cells is required for the formation of IgE antibody. The purpose of the chapter is to analyze the cellular events involved in the IgE antibody response in different experimental systems in comparison with the IgG antibody response. Basic work on IgE antibodies and their role in reaginic hypersensitivity is discussed. The extension to the cellular regulation of IgE antibodies is continued in various experimental animals. The important role of both helper and suppressor T cells in this regulation is quite apparent. Immunoglobulin E antibody formation in vivo and in vitro and the immunological factors essential for IgE antibody responses are discussed. Promising approaches to therapy derived from the animal model work are also proposed. Cellular basis and the regulation of IgE antibody response are also described. The discussion of the mechanisms for induction and suppression of IgE antibody response provides a clue to future therapy for atopic diseases.
ASJC Scopus subject areas
- Immunology and Allergy