Cellular and molecular features of neurogenic skeletal muscle atrophy

Jeffrey T. Ehmsen, Ahmet Höke

Research output: Contribution to journalReview articlepeer-review

Abstract

Neurogenic atrophy refers to the loss of muscle mass and function that results directly from injury or disease of the peripheral nervous system. Individuals with neurogenic atrophy may experience reduced functional status and quality of life and, in some circumstances, reduced survival. Distinct pathological findings on muscle histology can aid in diagnosis of a neurogenic cause for muscle dysfunction, and provide indicators for the chronicity of denervation. Denervation induces pleiotypic responses in skeletal muscle, and the molecular mechanisms underlying neurogenic muscle atrophy appear to share common features with other causes of muscle atrophy, including activation of FOXO transcription factors and corresponding induction of ubiquitin-proteasomal and lysosomal degradation. In this review, we provide an overview of histologic features of neurogenic atrophy and a summary of current understanding of underlying mechanisms.

Original languageEnglish (US)
Article number113379
JournalExperimental Neurology
Volume331
DOIs
StatePublished - Sep 2020

Keywords

  • Denervation
  • Lysosome
  • Neurogenic atrophy
  • Proteolysis
  • Skeletal muscle
  • Ubiquitin ligase

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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